Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 20201
Kirsten E. Wiens, Pinyi Nyimol Mawien, John Rumunu, Damien Slater, Forrest K. Jones, Serina Moheed, Andrea Caflisch, Bior K. Bior, Iboyi Amanya Jacob, Richard Lino Lako, Argata Guracha Guyo, Olushayo Oluseun Olu, Sylvester Maleghemi, Andrew Baguma, Juma John Hassen, Sheila K. Baya, Lul Deng, Justin Lessler, Maya N. Demby, Vanessa Sanchez, Rachel Mills, Clare Fraser, Richelle C. Charles2
, Jason B. Harris2
, Andrew S. Azman3
, and Joseph F. Wamala3
Author affiliations: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (K.E. Wiens, F.K. Jones, J. Lessler, M.N. Demby, A.S. Azman); Republic of South Sudan Ministry of Health, Juba, South Sudan (P.N. Mawien, J. Rumunu, B.K. Bior, I.A. Jacob, R.L. Lako, L. Deng); Massachusetts General Hospital, Boston, Massachusetts, USA (D. Slater, S. Moheed, V. Sanchez, R. Mills, C. Fraser, R.C. Charles, J.B. Harris); International Organization for Migration, Juba (A. Caflisch); World Health Organization, Juba (A.G. Guyo, O.O. Olu, S. Maleghemi, A. Baguma, J.J. Hassen, S.K. Baya, J.F. Wamala); Kabale University School of Medicine, Kabale, Uganda (A. Baguma); Harvard Medical School, Boston (R.C. Charles, J.B. Harris); Médecins Sans Frontières, Geneva, Switzerland (A.S. Azman); Institute of Global Health, Geneva (A.S. Azman)
Figure 2. Effects of changing percentage of assumed mild cases in the population on adjusted seroprevalence of severe acute respiratory syndrome coronavirus 2 IgG in Juba, South Sudan. A) Mean adjusted seroprevalence; B) ratio of unreported to reported infections. Error bars represent 95% credible intervals. Dashed line in panel A represents unadjusted seropositivity at 22.3%. Unreported infections in panel B based on 1,873 confirmed coronavirus disease cases in Juba (as of August 31, 2020) and an approximate population of 510,000 in Juba. The x-axis in both panels indicates percentage of mild cases included in the synthetic positive control dataset used to estimate assay sensitivity.
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