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Volume 27, Number 6—June 2021
Research

Seroprevalence of Severe Acute Respiratory Syndrome Coronavirus 2 IgG in Juba, South Sudan, 20201

Kirsten E. Wiens, Pinyi Nyimol Mawien, John Rumunu, Damien Slater, Forrest K. Jones, Serina Moheed, Andrea Caflisch, Bior K. Bior, Iboyi Amanya Jacob, Richard Lino Lako, Argata Guracha Guyo, Olushayo Oluseun Olu, Sylvester Maleghemi, Andrew Baguma, Juma John Hassen, Sheila K. Baya, Lul Deng, Justin Lessler, Maya N. Demby, Vanessa Sanchez, Rachel Mills, Clare Fraser, Richelle C. Charles2, Jason B. Harris2, Andrew S. Azman3Comments to Author , and Joseph F. Wamala3
Author affiliations: Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA (K.E. Wiens, F.K. Jones, J. Lessler, M.N. Demby, A.S. Azman); Republic of South Sudan Ministry of Health, Juba, South Sudan (P.N. Mawien, J. Rumunu, B.K. Bior, I.A. Jacob, R.L. Lako, L. Deng); Massachusetts General Hospital, Boston, Massachusetts, USA (D. Slater, S. Moheed, V. Sanchez, R. Mills, C. Fraser, R.C. Charles, J.B. Harris); International Organization for Migration, Juba (A. Caflisch); World Health Organization, Juba (A.G. Guyo, O.O. Olu, S. Maleghemi, A. Baguma, J.J. Hassen, S.K. Baya, J.F. Wamala); Kabale University School of Medicine, Kabale, Uganda (A. Baguma); Harvard Medical School, Boston (R.C. Charles, J.B. Harris); Médecins Sans Frontières, Geneva, Switzerland (A.S. Azman); Institute of Global Health, Geneva (A.S. Azman)

Main Article

Figure 2

Effects of changing percentage of assumed mild cases in the population on adjusted seroprevalence of severe acute respiratory syndrome coronavirus 2 IgG in Juba, South Sudan. A) Mean adjusted seroprevalence; B) ratio of unreported to reported infections. Error bars represent 95% credible intervals. Dashed line in panel A represents unadjusted seropositivity at 22.3%. Unreported infections in panel B based on 1,873 confirmed coronavirus disease cases in Juba (as of August 31, 2020) and an approximate population of 510,000 in Juba. The x-axis in both panels indicates percentage of mild cases included in the synthetic positive control dataset used to estimate assay sensitivity.

Figure 2. Effects of changing percentage of assumed mild cases in the population on adjusted seroprevalence of severe acute respiratory syndrome coronavirus 2 IgG in Juba, South Sudan. A) Mean adjusted seroprevalence; B) ratio of unreported to reported infections. Error bars represent 95% credible intervals. Dashed line in panel A represents unadjusted seropositivity at 22.3%. Unreported infections in panel B based on 1,873 confirmed coronavirus disease cases in Juba (as of August 31, 2020) and an approximate population of 510,000 in Juba. The x-axis in both panels indicates percentage of mild cases included in the synthetic positive control dataset used to estimate assay sensitivity.

Main Article

1A portion of this research was presented at the United States–Japan Cooperative Medical Sciences Program—Virtual Workshop on COVID-19, February 24–26, 2021.

2These authors contributed equally to this article.

3These authors contributed equally to this article.

Page created: March 25, 2021
Page updated: May 18, 2021
Page reviewed: May 18, 2021
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