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Volume 28, Number 1—January 2022
Dispatch

Emergence of Difficult-to-Treat Tinea Corporis Caused by Trichophyton mentagrophytes Complex Isolates, Paris, France

Sarah Dellière1Comments to Author , Brune Joannard1, Mazouz Benderdouche, Anselme Mingui, Maud Gits-Muselli, Samia Hamane, Alexandre Alanio, Antoine Petit, Germaine Gabison, Martine Bagot, and Stéphane Bretagne
Author affiliations: Hôpital Saint Louis Laboratoire de Parasitologie-Mycologie, Assistance Publique des Hôpitaux de Paris, Paris, France (S. Dellière, B. Joannard, M. Benderdouche, A. Mingui, M. Gits-Muselli, S. Hamane, A. Alanio, S. Bretagne); Université de Paris, Paris (S. Dellière, M. Gits-Muselli, A. Alanio, M. Bagot, S. Bretagne); Centre National de Référence Mycoses Invasives et Antifongiques Unité de Mycologie Moléculaire, Paris (A. Alanio, S. Bretagne); Hôpital Saint-Louis Service de Dermatologie, Assistance Publique des Hôpitaux de Paris, Paris (A. Petit, G. Gabison, M. Bagot); INSERM U976 (M. Bagot)

Main Article

Figure 2

Phylogenetic tree of clinically resistant Trichophyton mentagrophytes complex internal transcribed spacer (ITS) type VIII (T. indotineae) isolates from patients in Paris, France (red) and control isolates (green) compared with reference isolates. Isolates were classified on the basis of the ITS regions of rDNA classified among existing isolates from type I to type IX strains retrieved from GenBank (3). All resistant isolates and control isolates 2 and 8 had non–wild-type SQLE sequence and different MIC profiles (Table 2). Tree was constructed based on maximum-likelihood (Tamura-Nei model) analysis including sequences of the reference Trichophyton mentagrophytes neotype strain (IHEM 4268NT). Reference isolates are identified by GenBank accession number; T. quinckeanum (Genbank accession nos. KJ606088.1 and KY680503.1) was used as outgroup.

Figure 2. Phylogenetic tree of clinically resistant Trichophyton mentagrophytes complex internal transcribed spacer (ITS) type VIII (T. indotineae) isolates from patients in Paris, France (red) and control isolates (green) compared with reference isolates. Isolates were classified on the basis of the ITS regions of rDNA classified among existing isolates from type I to type IX strains retrieved from GenBank (3). All resistant isolates and control isolates 2 and 8 had non–wild-type SQLE sequence and different MIC profiles ([[ANCHOR###T2###Table 2###Anchor]]). Tree was constructed based on maximum-likelihood (Tamura-Nei model) analysis including sequences of the reference Trichophyton mentagrophytes neotype strain (IHEM 4268NT). Reference isolates are identified by GenBank accession number; T. quinckeanum (Genbank accession nos. KJ606088.1 and KY680503.1) was used as outgroup.

Main Article

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1These authors contributed equally to this article.

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