Volume 28, Number 10—October 2022
Research
SARS-CoV-2 Vaccine Breakthrough by Omicron and Delta Variants, New York, USA
, Alexis Russell, Jonathan Plitnick, Jemma V. Rowlands, Daryl M. Lamson, Eli Rosenberg, and Kirsten St. George
Table 2
Variables most associated with an Omicron variant in 3 analyses of SARS-CoV-2 vaccine breakthrough during the emergence period of the Omicron variant, New York, USA*
| Model | ΔAIC | Odds ratio (95% CI) |
||
|---|---|---|---|---|
| Parameter 1 | Parameter 2 | Parameter 3 | ||
| Main analysis | ||||
| Vaccination status | 0 | Vaccinated: 3.1 (2.0–4.9)† | Vaccinated + boosted: 6.7 (3.4–13.0)† | |
| Vaccine type | 3.33 | Pfizer | Moderna | Janssen |
| Without booster | 3.3 (1.9–5.6)† | 3.6 (2.0–6.7)† | 2.0 (0.8–5.1) | |
| With booster |
10.4 (4.3–25.2)† |
3.8 (1.5–9.3)‡ |
||
| Age analysis | ||||
| Vaccination status + age + age groups | 0.00 | Vaccinated: 4.8 (2.8–8.1)† | Vaccinated + boosted: 38.5 (15.9–93.2)† | Age, linear: 0.964 (0.950–0.978);† age 0–4 y: 0.250 (0.059–1.051); age 18–29 y: 2.0 (1.1–3.7)§ |
| Vaccination status + age |
7.41 |
Vaccinated:
5.0 (3.0–8.3)† |
Vaccinated + boosted: 34.1 (14.6–79.5)† |
Age: 0.962 (0.950–0.974)† |
| Vaccination-only analysis | ||||
| Janssen + days after dose | 0.00 | Janssen, relative to mRNA vaccine: 0.388 (0.149–1.009) | Days after last dose, booster or primary series: 0.996 (0.993–0.999)‡ | |
| Vaccine type + days after dose | 1.18 | Moderna, relative to Pfizer: 0.776 (0.448–1.344) | Janssen, relative to Pfizer: 0.351 (0.132–0.935)§ | Days after last dose, booster or primary series:0.996 (0.993–0.999)‡ |
*Only 1 boosted person had received an initial dose of Janssen vaccine, so for statistical reasons, this person was pooled with the unboosted Janssen recipients. When fit separately, the odds ratio for unboosted Janssen recipients was 1.9 (0.8–4.9) with a parameter p value of 0.20, and the parameter estimate for the single boosted Janssen individual was unreliable. Janssen vaccine, Janssen/Johnson & Johnson (https://www.jnj.com); Pfizer vaccine, Pfizer-BioNTech (https://www.pfizer.com); Moderna vaccine, Moderna (https://www.modernatx.com). ΔAIC, change in Akaike information criterion. †p<0.001. ‡p<0.01. §p<0.05.