Marcela Helena Gambim Fonseca
, Ana Carolina Matias Dinelly Pinto, Maria Francilene Souza Silva, Amanda Campelo Lima de Melo, Germana Silva Vasconcelos, Eduardo Ruback dos Santos, Fernanda Montenegro de Carvalho Araújo, and Luiz Odorico Monteiro de Andrade
Figure 2. Comparison of antibody response over time among healthcare workers vaccinated with 2 doses of CoronaVac vaccine (https://www.sinovac.com) followed by a BNT162b2 vaccine (Pfizer-BioNTech, https://www.pfizer.com) booster dose, by COVID-19 positivity status. A) S and N IgG seropositivity. B) S IgG levels. C) N IgG levels. Antibody responses were evaluated before vaccination (timepoint P1); 28 days after the first dose of CoronaVac vaccine (P2); 30 (P3) 90 (P4), 180 (P5), and 230 (P6) days after the second dose of CoronaVac vaccine; and 15 days after the booster dose with BNT162b2 vaccine (P7). For panels B and C, black lines indicate median levels values and error bars interquartile ranges; the horizontal dotted line indicates the cutoff value of the assays. Numbers below p values indicate numbers of COVID-19–positive and COVID-19–negative persons in each timepoint. Statistical analysis performed using the Kruskal–Wallis test with subsequent Dunn’s multiple testing correction. N, nucleocapsid protein; S, spike protein; S/CO, signal-to-cutoff ratio; (–), COVID-19 negative; (+), COVID-19 positive.