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Volume 28, Number 7—July 2022

Novel Mycobacterium tuberculosis Complex Genotype Related to M. caprae

Joseph Shea, Carol Smith, Tanya A. Halse, Donna Kohlerschmidt, Amy K. Rourke, Kimberlee A. Musser, Vincent Escuyer, and Pascal LapierreComments to Author 
Author affiliation: Wadsworth Center, New York State Department of Health, Albany, New York, USA

Main Article


List of markers used for species and lineage determination in investigation of novel Mycobacterium tuberculosis complex genotype related to M. caprae*

Species and lineage Specific markers Strain 20-2359 genotype
Mycobacterium tuberculosis
gyrB403 GCG + katG203 ACC
gyrB403 TCG + katG203 ACT
M. africanum ethA124 GAC + nt1673338 A or ethA124 GGC + nt1673338 C
inhA78 GCG + atpE69 GCT
inhA78 GTG + atpE69 GCG
M. pinnipedii inhA107 TCG + nt1473094 C inhA107 CCG + nt1473094 G
M. microti gyrB144 TAT + nt1473079 A gyrB144 TAC + nt1473079 C
M. caprae gyrB171 GTA + gyrB356 GCG gyrB171 GTA + gyrB356 GCT
M. bovis bacillus Calmette-Guérin pncA57 GAC + furA43 GTC pncA57 CAC + furA43 GCC
M. bovis
pncA57 GAC + furA43 GCC
pncA57 CAC + furA43 GCC
1 (Indo-Oceanic) gidB110 GTT gidB110 GTG
2 (Beijing) gidB92 GAC gidB92 GAA
3 (Central-Asian) nt2726105 A nt2726105 G
4 (Euro-American) katG463 CGG katG463 CTG
5 (West African 1) ethA124 GAC ethA124 GGC
6 (West African 2) inhA78 GCG inhA78 GTG

*The codons or individual nucleotide positions were based on the sequence of the reference genome H37Rv. None of the complete marker set are present in strain 20-2359; 2 partial matches are in bold. Three primate (SRR1792164, SRR1792165, SRR7617662) and 2 elephant (DRR120408, DRR120409) isolates shared the same genotypes with 20-2359 for these markers.

Main Article

Page created: May 10, 2022
Page updated: June 18, 2022
Page reviewed: June 18, 2022
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