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Volume 28, Number 9—September 2022
Research

Revised Definitions of Tuberculosis Resistance and Treatment Outcomes, France, 2006–2019

Yousra KherabiComments to Author , Mathilde Fréchet-Jachym, Christophe Rioux, Yazdan Yazdanpanah, Frédéric Méchaï, Valérie Pourcher, Jérôme Robert, Lorenzo Guglielmetti, and for the MDR-TB Management Group
Author affiliations: Assistance Publique Hôpitaux de Paris, Hôpital Bichat-Claude Bernard, Paris, France (Y. Kherabi, C. Rioux, Y. Yazdanpanah); Sorbonne Université, INSERM U1135, Paris (Y. Kherabi, J. Robert, L. Guglielmetti); Centre Hospitalier de Bligny, Briis-sous-Forges, France (M. Frechet-Jachym); Assistance Publique—Hopitaux de Paris, Paris (C. Rioux, Y. Yazdanpanah); INSERM U1137, IAME, Université de Paris, Paris (Y. Yazdanpanah); Universite Paris Diderot, Paris (Y. Yazdanpanah); Assistance Publique Hôpitaux de Paris, Hôpital Avicenne, Paris (F. Méchaï); Hopital Avicenne, Bobigny, France (F. Méchaï); Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris (V. Pourcher); Assistance Publique Hôpitaux de Paris, Sorbonne-Université, Hôpital Pitié-Salpêtrière, Paris (J. Robert, L. Guglielmetti)

Main Article

Table 5

Multivariable Cox proportional hazard model for sputum conversion in 214 patients affected by MDR TB and with positive sputum culture at baseline, France, 2006–2019*

Characteristic
 aHR (95% CI)
 p value
TB resistance status
Fluoroquinolone-susceptible MDR Referent
Pre-XDR/XDR
 0.59 (0.42–0.84)
 0.003
Diabetes
No Referent
Yes
 1.54 (0.79–2.97)
 0.20
Treatment adherence†
Good Referent
Poor
 1.40 (0.88–2.25)
 0.16
Addiction to alcohol
No Referent
Yes 0.61 (0.38–0.99) 0.04

*We used multiple imputation for missing data. Results are from the final model. aHR, adjusted hazard ratio. †Assessed by treating physician.

Main Article

Page created: July 31, 2022
Page updated: August 19, 2022
Page reviewed: August 19, 2022
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