Volume 28, Number 9—September 2022
Research Letter
Correlation between Clinical and Wastewater SARS-CoV-2 Genomic Surveillance, Oregon, USA
Devrim Kaya, Rebecca Falender, Tyler Radniecki, Matthew Geniza, Paul Cieslak, Christine Kelly, Noah Lininger, and Melissa Sutton
Table
Correlation between estimated SARS-CoV-2 variant proportions detected in clinical specimens and wastewater samples, Oregon, USA, February 7, 2021–February 26, 2022*
| Variant | r | R2 | p value | No. (%) pairwise observations included in correlation |
|---|---|---|---|---|
| All | 0.97 | 0.94 | <0.0001 | 233 (100) |
| Alpha B.1.1.7† | 0.96 | 0.93 | <0.0001 | 48 (20.6) |
| Beta B.1.351 | 0.61 | 0.38 | 0.0003 | 30 (12.9) |
| Delta B.1.617.2‡ | 0.98 | 0.97 | <0.0001 | 55 (23.6) |
| Epsilon B.1.427/429 | 0.86 | 0.74 | <0.0001 | 44 (18.9) |
| Gamma P.1§ | 0.71 | 0.50 | <0.0001 | 44 (18.9) |
| Omicron B.1.1.529¶ | 0.97 | 0.93 | <0.0001 | 12 (5.2) |
*Sequence data for clinical samples were retrieved from GISAID (https://www.gisaid.org). r, Pearson correlation coefficient; R2, simple linear regression with a least-squares regression line to assess model fit. †B.1.1.7 includes all Q sublineages. ‡B.1.617.2 includes all AY sublineages. §P.1 includes all P.1 sublineages. ¶B.1.1.529 includes all BA sublineages.
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