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Volume 29, Number 1—January 2023
Research

Akkermansia muciniphila Associated with Improved Linear Growth among Young Children, Democratic Republic of the Congo

Christine Marie GeorgeComments to Author , Alves Birindwa, Shan Li, Camille Williams, Jennifer Kuhl, Elizabeth Thomas, Ruthly François, Amani Sanvura Presence, Bisimwa Rusanga Jean Claude, Patrick Mirindi, Lucien Bisimwa, Jamie Perin, and O. Colin Stine
Author affiliations: Johns Hopkins Bloomberg School of Public Health Department of International Health, Baltimore, Maryland, USA, and Bukavu, Democratic Republic of the Congo (C.M. George, A. Birindwa, C. Williams, J. Kuhl, E. Thomas, R. François, A.S. Presence, B.R. Jean Claude, L. Bisimwa, J. Perin); University of Maryland School of Medicine Department of Epidemiology and Public Health, Baltimore (S. Li, O.C. Stine); Food for the Hungry, Washington DC, USA, and Bukavu (P. Mirindi)

Main Article

Table 3

Associations between enteric pathogens and anthropometric measurements for participants in study of Akkermansia muciniphila association with improved linear growth among young children, Democratic Republic of the Congo*

Category
 Change from baseline to 6-month follow-up, coefficient (95% CI)
Height-for-age z-score
 Weight-for-height/length z-scores
 Weight-for-age z-score
Pathogen or microbe, presence vs. absence
No. pathogens 0.08 (–0.05 to 0.21) –0.01 (–0.15 to 0.14) 0.06 (–0.04 to 0.15)
Giardia 0.27 (–0.25 to 0.80) –0.13 (–0.84 to 0.58) 0.02 (–0.36 to 0.41)
Shigella 0.01 (–0.30 to 0.33) 0.11 (–0.20 to 0.42) 0.03 (–0.21 to 0.27)
Cryptosporidium 0.37 (–0.08 to 0.81) –0.41 (–0.83 to 0.0008) 0.00 (–0.38 to 0.37)
ETEC 0.11 (–0.19 to 0.42) –0.26 (–0.60 to 0.09) 0.04 (–0.27 to 0.34)
Campylobacter jejuni 0.09 (–0.15 to 0.34) 0.11 (–0.17 to 0.40) 0.16 (–0.05 to 0.37)
Akkermansia muciniphila 0.34 (0.02–0.67) –0.04 (–0.37 to 0.28) 0.23 (–0.01 to 0.47)
Lactobacillus salivarius
 –0.12 (–0.40 to 0.17)
 –0.01 (–0.29 to 0.27)
 –0.03 (–0.26 to 0.19)
Pathogen or microbe, log transformed presence vs. absence
Giardia 0.01 (–0.02 to 0.04) –0.01 (–0.04 to 0.03) 0.0005 (–0.02 to 0.02)
Shigella 0.0007 (–0.02 to 0.02) 0.01 (–0.01 to 0.03) 0.01 (–0.01 to 0.02)
Cryptosporidium 0.02 (–0.01 to 0.05) –0.03 (–0.05 to 0.005) –0.01 (–0.03 to 0.02)
ETEC –0.01 (–0.03 to 0.01) 0.0004 (–0.02 to 0.02) 0.003 (–0.01 to 0.02)
Campylobacter jejuni 0.004 (–0.01 to 0.02) 0.002 (–0.02 to 0.02) 0.01 (–0.01 to 0.02)
Akkermansia muciniphila 0.02 (0.001 to 0.04) –0.01 (–0.03 to 0.01) 0.01 (–0.01 to 0.02)
Lactobacillus salivarius –0.01 (–0.04 to 0.02) 0.00 (–0.03 to 0.03) –0.001 (–0.02 to 0.02)

*Models adjusted for wall type, household educational level, number of persons in the household, animal source food, and breastfeeding. ETEC, enterotoxigenic Escherichia coli.

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Page created: September 22, 2022
Page updated: December 21, 2022
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