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Volume 29, Number 1—January 2023

Research Letter

SARS-CoV-2 Omicron BA.5 Infections in Vaccinated Persons, Rural Uganda

Joseph Mugisha, Bernard Mpairwe, Robert Newton, Matthew CottenComments to Author , and My V.T. Phan
Author affiliations: Medical Research Council/Uganda Virus Research Institute and London School of Hygiene & Tropical Medicine, Uganda Research Unit, Entebbe, Uganda (J. Mugisha, B. Mpairwe, R. Newton, M. Cotten, M.V.T. Phan); University of York, York, United Kingdom (R. Newton); Medical Research Council–University of Glasgow Center for Virus Research, Glasgow, Scotland, United Kingdom (M. Cotten)

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Figure

Nucleotide changes between SARS-CoV-2 genomes from a cluster of COVID-19–positive persons in Kyamulibwa, Kalungu District, rural Uganda. The lower portion of the chart shows nucleotide differences from the case 1 genome, plotted as white bars. The absence of bars in the BA.5.2.1 genomes from cases 1, 2, 7, and 10 indicates identical sequences. Case 5 was determined to be lineage BA.2.31, and cases 4, 6, 11, and 12 genomes demonstrated virus variants of lineage BA.5.2.1 distinct from the genomes from cases 1, 2, 7, and 10. A schematic of the SARS-CoV-2 genome is shown in the top portion of the chart, with protein coding regions marked.

Figure. Nucleotide changes between SARS-CoV-2 genomes from a cluster of COVID-19–positive persons in Kyamulibwa, Kalungu District, rural Uganda. The lower portion of the chart shows nucleotide differences from the case 1 genome, plotted as white bars. The absence of bars in the BA.5.2.1 genomes from cases 1, 2, 7, and 10 indicates identical sequences. Case 5 was determined to be lineage BA.2.31, and cases 4, 6, 11, and 12 genomes demonstrated virus variants of lineage BA.5.2.1 distinct from the genomes from cases 1, 2, 7, and 10. A schematic of the SARS-CoV-2 genome is shown in the top portion of the chart, with protein coding regions marked.

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Page created: November 04, 2022
Page updated: December 22, 2022
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