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Volume 29, Number 11—November 2023
Research

Global Phylogeography and Genomic Epidemiology of Carbapenem-Resistant blaOXA-232–Carrying Klebsiella pneumoniae Sequence Type 15 Lineage

Yuye Wu, Tian Jiang, Xianhong He, Jiayu Shao, Chenghao Wu, Weifang Mao, Huiqiong Jia, Fang He, Yingying Kong, Jianyong Wu, Qingyang Sun, Long Sun, Mohamed S. Draz, Xinyou XieComments to Author , Jun ZhangComments to Author , and Zhi RuanComments to Author 
Author affiliations: Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, China (Y. Wu, T. Jiang, X. He, J. Shao, C. Wu, W. Mao, Y. Kong, X. Xie, J. Zhang, Z. Ruan); Wenzhou Medical University Affiliated Wenling Hospital, Taizhou, China (T. Jiang); Third People's Hospital of Xiaoshan District, Hangzhou (X. He, J. Shao); Shaoxing University Affiliated Hospital, Shaoxing, China (W. Mao); Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou (H. Jia); Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou (H. Jia); Zhejiang Provincial People's Hospital, Hangzhou (F. He); Key Laboratory of Precision Medicine in Diagnosis and Monitoring Research of Zhejiang Province, Hangzhou (Y. Kong, X. Xie, J. Zhang, Z. Ruan); Zhejiang University School of Medicine Fourth Affiliated Hospital, Hangzhou (J. Wu); No. 903 Hospital of PLA Joint Logistic Support Force, Hangzhou (Q. Sun); Hangzhou Women's Hospital, Hangzhou (L. Sun); Case Western Reserve University School of Medicine, Cleveland, Ohio, USA (M.S. Draz); Cleveland Clinic, Cleveland (M.S. Draz)

Main Article

Table 2

MICs for different antimicrobial drugs of 21 blaOXA-232–carrying sequence type 15 carbapenem-resistant Klebsiella pneumoniae isolates from patients in China*

Isolate MIC, mg/L
AMK ATM FOF FOX FEP CTX LVX IPM MEM CST TGC FDC CZA
KP3 >128 >128 >128 64 >64 >128 64 8 4 <0.0625 1 2 0.25/0.125
KP41 >128 >128 >128 16 >64 >128 16 4 2 <0.0625 0.25 2 0.5/0.25
KP105 >128 >128 >128 128 >64 >128 128 >128 >128 <0.0625 2 1 0.5/0.25
KP232 >128 >128 128 128 >64 >128 >128 8 4 0.0625 2 0.5 0.5/0.25
KP306 >128 >128 >128 64 >64 >128 64 4 4 <0.0625 1 4 0.25/0.125
KP5 >128 >128 >128 64 64 >128 32 2 4 0.5 2 0.25 2/1
KP441 >128 >128 >128 32 >64 >128 16 0.5 2 0.125 2 1 2/1
KP68 >128 >128 >128 64 >64 >128 32 32 32 0.5 1 1 4/2
KP76 >128 >128 >128 32 >64 >128 16 1 1 0.25 1 1 1/0.5
KP77 >128 >128 >128 32 >64 >128 16 0.5 1 0.5 2 0.5 2/1
KP79 >128 >128 >128 32 >64 >128 32 1 1 0.25 1 16 2/1
KP81 >128 >128 >128 128 >64 >128 128 16 32 0.125 4 1 2/1
KP85 >128 >128 >128 32 >64 >128 16 2 1 0.125 1 0.25 2/1
KP89 >128 >128 >128 32 >64 >128 32 1 2 0.125 2 0.25 2/1
KP91 >128 >128 >128 128 >64 >128 64 1 2 0.125 0.5 0.5 1/0.5
KP97 >128 >128 >128 64 >64 >128 128 16 32 0.0625 2 1 2/1
KP9112 >128 >128 >128 64 >64 >128 64 2 2 <0.0625 1 0.5 2/1
KP135 >128 >128 >128 64 64 >128 64 4 2 0.5 2 0.25 2/1
KP8474 >128 >128 >128 >128 >64 >128 64 1 2 0.0625 1 0.5 2/1
KP12339 >128 >128 >128 32 >64 >128 16 1 2 0.125 0.5 0.5 2/1
KP3295 >128 64 >128 >128 >64 >128 >128 32 32 0.25 0.25 0.5 0.25/0.125

*By broth microdilution method for amikacin, aztreonam, fosfomycin, cefoxitin, cefepime, cefotaxime, cefiderocol, levofloxacin, imipenem, meropenem, polymyxin, tigecycline, and ceftazidime/avibactam; iron-depleted cation-adjusted Mueller-Hinton broth in custom-prepared MIC panels (14) method for cefiderocol. Breakpoints are according to Clinical and Laboratory Standards Institute 2020 (https://clsi.org) and EUCAST 10.0 (https://www.eucast.org/clinical_breakpoints) guidelines. Escherichia coli ATCC 25922 was the quality control strain. AMK, amikacin; ATM, aztreonam; FOF, fosfomycin; FOX, cefoxitin; FEP, cefepime; CTX, cefotaxime; LVX, levofloxacin; IPM, imipenem; MEM, meropenem; CST, colistin; TGC, tigecycline; FDC, cefiderocol; CZA, ceftazidime/avibactam.

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