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Volume 29, Number 11—November 2023
Research

Genotypic Evolution of Klebsiella pneumoniae Sequence Type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol Treatment, Italy

Gabriele Arcari, Federico Cecilia, Alessandra Oliva, Riccardo Polani, Giammarco Raponi, Federica Sacco, Alice De Francesco, Francesco Pugliese, and Alessandra CarattoliComments to Author 
Author affiliations: Sapienza University of Rome, Rome, Italy (G. Arcari, F. Cecilia, A. Oliva, R. Polani, G. Raponi, A. De Francesco, F. Pugliese, A. Carattoli); Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome (A. Oliva, G. Raponi, F. Sacco, F. Pugliese)

Main Article

Figure 2

Phylogenetic analysis and genetic features of Klebsiella pneumoniae ST512 in study of the strain’s genotypic evolution during ceftazidime/avibactam, meropenem/vaborbactam, and cefiderocol treatment, Italy. Phylogenetic tree was constructed from 4,654 core gene alignments from a total of 133 K. pneumoniae ST512 genome sequences: 5 genomes sequenced in this study (pink shading), 12 genomes from the same hospital (pale blue shading), and 116 genomes downloaded from the Pasteur Institute BIGSdb database (https://bigsdb.pasteur.fr/klebsiella). Colors indicate resistance and acquired-resistance genes (or corresponding proteins) associated with carbapenemases, yersiniabactin, and chromosomal mutations within the different strains. The same color in the legend on the left indicates the expected resistance phenotype. Asterisk after CirA E133 indicates this mutation produced a premature stop codon. Scale bar indicates number of single-nucleotide polymorphisms in the core genome. Del, deletion; KPC, K. pneumoniae carbapenemase; PUI, Policlinico Umberto I; ST, sequence type; VIM, Verona integron-encoded metallo-β-lactamase.

Figure 2. Phylogenetic analysis and genetic features of Klebsiella pneumoniae ST512 in study of the strain’s genotypic evolution during ceftazidime/avibactam, meropenem/vaborbactam, and cefiderocol treatment, Italy. Phylogenetic tree was constructed from 4,654 core gene alignments from a total of 133 K. pneumoniae ST512 genome sequences: 5 genomes sequenced in this study (pink shading), 12 genomes from the same hospital (pale blue shading), and 116 genomes downloaded from the Pasteur Institute BIGSdb database (https://bigsdb.pasteur.fr/klebsiella). Colors indicate resistance and acquired-resistance genes (or corresponding proteins) associated with carbapenemases, yersiniabactin, and chromosomal mutations within the different strains. The same color in the legend on the left indicates the expected resistance phenotype. Asterisk after CirA E133 indicates this mutation produced a premature stop codon. Scale bar indicates number of single-nucleotide polymorphisms in the core genome. Del, deletion; KPC, K. pneumoniae carbapenemase; PUI, Policlinico Umberto I; ST, sequence type; VIM, Verona integron-encoded metallo-β-lactamase.

Main Article

Page created: September 05, 2023
Page updated: November 02, 2023
Page reviewed: November 02, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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