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Volume 29, Number 12—December 2023
Dispatch

Autochthonous Dengue Outbreak, Paris Region, France, September–October 2023

Marta Zatta1Comments to Author , Ségolène Brichler, William Vindrios, Giovanna Melica, and Sébastien Gallien1
Author affiliations: Henri Mondor University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France (M. Zatta, W. Vindrios, G. Melica, S. Gallien); Avicenne University Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France (S. Brichler)

Main Article

Table

Clinical and laboratory findings in an outbreak of autochthonous dengue, Paris Region, France, September–October 2023*

Clinical, epidemiologic and laboratory parameters Case-patient 1
 Case-patient 2 Case-patient 3
Date of symptom onset
 Sep 13
 Sep 11
 Sep 14
Symptoms
 Fever, malaise, frontal headache, nausea and vomiting
 Fever, malaise, frontal headache, and maculopapular rash
 Fever, chills, frontal headache, myalgia, papular rash, and trunk and upper limbs itching
Date of symptom resolution
 Sep 21
 Sep 14
Sep 21
Epidemiologic link
 Index case
 Household contact of index case
 Household contact of index case
Sample collection dates
 Sep 19
 Sep 22
 Oct 7
 Oct 13
 Oct 13
Delay between sample collection and symptom onset, d
 7
 10
 25
 33
 30
DENV RNA in blood
 DENV-2†
 Not tested
 Not tested
 Not tested
 Not tested
DENV NS1 antigen
 Positive‡
 Not tested
 Not tested
 Not tested
 Not tested
DENV IgM
 Not tested
 Positive.§ r = 72
 Positive.§ r = 70
 Positive,¶ r = 30
 Positive,¶ r = 28
DENV IgG Not tested Negative.§ r<5 Positive.§ r = 12 Positive,¶ r = 15 Positive,¶ r = 17

*DENV, dengue virus; NS1, nonstructural protein 1; r, ratio; RT-PCR, reverse transcription PCR. †DENV RNA was amplified, after purifying total nucleic acids from plasma, by real-time RT-PCR by using Realstar Dengue RT-PCR kit 3.0 and RealStar Dengue Type RT-PCR Kit 1.0 (Altona Diagnostics, https://www.altona-diagnostics.com). ‡DENV NS1 antigen was detected in plasma by using Dengue NS1 Ag Strips (Biosynex SA, https://www.biosynex.com) immunochromatographic assay. §DENV IgM and IgG were detected by using Virclia Dengue IgM/IgG (Orgentec, https://www.orgentec.com/en) chemiluminescence immunoassay; results are positive if r>11. ¶DENV IgM and IgG were detected by Vircell Dengue IgM/IgG (Orgentec) ELISA immunoassay; results are positive if r>11.

Main Article

1These authors contributed equally to this article.

Page created: November 06, 2023
Page updated: November 18, 2023
Page reviewed: November 18, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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