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Volume 29, Number 2—February 2023
CME ACTIVITY - Synopsis

Crimean-Congo Hemorrhagic Fever, Spain, 2013–2021

Helena Miriam Lorenzo Juanes1, Cristina Carbonell1, Begoña Febrer Sendra, Amparo López-Bernus, Alberto Bahamonde, Alberto Orfao, Carmen Vieira Lista, María Sánchez Ledesma, Ana Isabel Negredo, Beatriz Rodríguez-Alonso, Beatriz Rey Bua, María Paz Sánchez-Seco, Juan Luis Muñoz Bellido, Antonio Muro, and Moncef Belhassen-GarcíaComments to Author 
Author affiliations: Universidad de Salamanca, Salamanca, Spain (H. Lorenzo-Juanes, C. Carbonell, B. Febrer-Sendra, A. López-Bernus, A. Orfao, C. Viera Lista, M. Sánchez Ledesma, B. Rodriguez Alonso, B. Rey Bua, J.L. Muñoz Bellido, A. Muro, M. Belhassen-Garcia); Instituto de Investigación Biomédica de Salamanca, Salamanca (H.M. Lorenzo Juanes, C. Carbonell, B. Febrer Sendra, A. López-Bernus, C. Vieira Lista, B. Rodriguez-Alonso, B. Rey Bua, M.P. Sánchez-Seco, A. Muro, M. Belhassen-Garcia); Hospital Universitario de Salamanca, Salamanca (H.M. Lorenzo Juanes, C. Carbonell, M. Sánchez Ledesma, B. Rodríguez-Alonso, B. Rey Bua); Hospital El Bierzo, Ponferrada, Spain (A. Bahamonde); Centro de Investigación del Cáncer, Salamanca (A. Orfao); Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain (A. Orfao); Centro Nacional de Microbiologiia, Majadahonda, Spain (A.I. Negredo, M.P. Sánchez-Seco); Red de Investigación Colaborativa en Enfermedades Tropicales, Madrid (A.I. Negredo, M.P. Sánchez-Seco, J.L. Muñoz Bellido); Centro de Investigación Biomédica en Red en Enfermedades Infecciosas, Madrid (A.I. Negredo, M.P. Sánchez-Seco)

Main Article

Figure 1

Locations of CCHF cases (A) and phylogenetic tree of CCHFV (B) in Spain, 2013–2021. Dots on the map indicate patients with a CCHF diagnosis in Spain: black dots indicate cases from this study, and colored dots indicate cases previously described. Two cases (patients 8 and 10) were not sequenced. The phylogenetic tree was constructed by the neighbor-joining method based on sequences of the small segment of the virus. The numbers on the right indicate bootstrap values for the groups; values <75 are not shown. Other sequences are listed by GenBank accession number, strain, geographic origin, and sampling year. Genotypes are indicated by Roman numerals according to Carroll et al. (14) with the equivalent clade nomenclature according to Chamberlain et al. (15) in brackets; I, West Africa (Africa 1); III, South and West Africa (Africa 3); IV, Middle East/Asia, divided into 2 groups (Asia 1/Asia 2); V, Europe/Turkey (Europe 1); VI, Greece (Europe 2). New lineage, Africa 4 described by Negredo et al. (12). CCHF, Crimean-Congo hemorrhagic fever; CCHFV, CCHF virus.

Figure 1. Locations of CCHF cases (A) and phylogenetic tree of CCHFV (B) in Spain, 2013–2021. Dots on the map indicate patients with a CCHF diagnosis in Spain: black dots indicate cases from this study, and colored dots indicate cases previously described. Two cases (patients 8 and 10) were not sequenced. The phylogenetic tree was constructed by the neighbor-joining method based on sequences of the small segment of the virus. The numbers on the right indicate bootstrap values for the groups; values <75 are not shown. Other sequences are listed by GenBank accession number, strain, geographic origin, and sampling year. Genotypes are indicated by Roman numerals according to Carroll et al. (14) with the equivalent clade nomenclature according to Chamberlain et al. (15) in brackets; I, West Africa (Africa 1); III, South and West Africa (Africa 3); IV, Middle East/Asia, divided into 2 groups (Asia 1/Asia 2); V, Europe/Turkey (Europe 1); VI, Greece (Europe 2). New lineage, Africa 4 described by Negredo et al. (12). CCHF, Crimean-Congo hemorrhagic fever; CCHFV, CCHF virus.

Main Article

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Main Article

1These authors contributed equally to this article.

Page created: January 23, 2023
Page updated: January 23, 2023
Page reviewed: January 23, 2023
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