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Volume 29, Number 2—February 2023
Research

Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection

David S. KhouryComments to Author , Timothy E. Schlub, Deborah Cromer, Megan Steain, Youyi Fong, Peter B. Gilbert, Kanta Subbarao, James A. Triccas, Stephen J. Kent, and Miles P. DavenportComments to Author 
Author affiliations: The University of New South Wales, Sydney, New South Wales, Australia (D.S. Khoury, D. Cromer, M.P. Davenport); University of Sydney, Sydney (T.E. Schlub, M. Steain, J.A. Triccas); Fred Hutchinson Cancer Research Center, Seattle, Washington, USA (Y. Fong, P.B. Gilbert); The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia (K. Subbarao, S.J. Kent); Monash University, Melbourne (S.J. Kent)

Main Article

Figure 3

Breakthrough-infection data and protection from SARS-CoV-2 infection showing the association between neutralizing antibody titer and protection from symptomatic SARS-CoV-2 infection for an individual person. A) BNT162b2 (Pfizer-BioNTech, https://www.pfizer.com) (5); B) mRNA-1273 (Moderna, https://www.modernatx.com), pseudovirus ID50 (4); C) ChAdOx1 (AstraZeneca, https://www.astrazeneca.com), live virus (3); D) ChAdOx 1, pseudovirus ID50 (3). The protection curve derived from the vaccine-comparison model (red dashed line and shading 95% CIs) is compared with the observed normalized frequencies of neutralization level (calculations in Appendix) of breakthrough infections reported in 3 studies (gray/black dots). Data from 2 mRNA vaccine studies of mRNA-1273 (A) and BNT162b2 (B), and the adenoviral vector vaccine ChAdOx1 nCoV19 (C, D) are shown. Lower opacity dots indicate fewer persons with neutralization titers in that range. Also shown in each panel are modelled protection curves showing the relationship between individual neutralizing antibodies and protection estimated in each breakthrough-infection study. Note: Breakthrough-infection data of BNT162b2 vaccinees were generously supplied by the authors of reference (5). The data were unavailable for the other 2 studies and were extracted from the original manuscripts; extraction of data from Gilbert et al. (4) was conducted manually and may be less reliable than that of the other studies (Appendix). ID50, 50% infectious dose; ID80, 80% infectious dose.

Figure 3. Breakthrough-infection data and protection from SARS-CoV-2 infection showing the association between neutralizing antibody titer and protection from symptomatic SARS-CoV-2 infection for an individual person. A) BNT162b2 (Pfizer-BioNTech, https://www.pfizer.com) (5); B) mRNA-1273 (Moderna, https://www.modernatx.com), pseudovirus ID50 (4); C) ChAdOx1 (AstraZeneca, https://www.astrazeneca.com), live virus (3); D) ChAdOx 1, pseudovirus ID50 (3). The protection curve derived from the vaccine-comparison model (red dashed line and shading 95% CIs) is compared with the observed normalized frequencies of neutralization level (calculations in Appendix) of breakthrough infections reported in 3 studies (gray/black dots). Data from 2 mRNA vaccine studies of mRNA-1273 (A) and BNT162b2 (B), and the adenoviral vector vaccine ChAdOx1 nCoV19 (C, D) are shown. Lower opacity dots indicate fewer persons with neutralization titers in that range. Also shown in each panel are modelled protection curves showing the relationship between individual neutralizing antibodies and protection estimated in each breakthrough-infection study. Note: Breakthrough-infection data of BNT162b2 vaccinees were generously supplied by the authors of reference (5). The data were unavailable for the other 2 studies and were extracted from the original manuscripts; extraction of data from Gilbert et al. (4) was conducted manually and may be less reliable than that of the other studies (Appendix). ID50, 50% infectious dose; ID80, 80% infectious dose.

Main Article

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Page created: December 20, 2022
Page updated: January 21, 2023
Page reviewed: January 21, 2023
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