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Volume 29, Number 3—March 2023
CME ACTIVITY - Synopsis

Bartonella spp. Infections Identified by Molecular Methods, United States

David W. McCormick, Sara L. Rassoulian-Barrett, Daniel R. Hoogestraat, Stephen J. Salipante, Dhruba SenGupta, Elizabeth A. Dietrich, Brad T. Cookson, Grace E. Marx1Comments to Author , and Joshua A. Lieberman1
Author affiliations: Centers for Disease Control and Prevention, Fort Collins, Colorado, USA (D.W. McCormick, E.A. Dietrich, G.E. Marx); University of Washington, Seattle, Washington, USA (S.L. Rassoulian-Barrett, D.R. Hoogestraat, S.J. Salipante, D. SenGupta, B.T. Cookson, J.A. Lieberman)

Main Article

Figure 1

Flow diagram showing clinical specimens included in the analysis in study of Bartonella spp. infections identified by molecular methods during 2003–2021 at an academic laboratory in the United States. If a patient had multiple specimens submitted >30 days apart, only information from the first Bartonella-positive specimen was included. Clinical specimens were tested for Bartonella spp. by PCR. A total of 430 specimens from 420 patients were included in the study. BT-PCR, B. henselae and B. quintana bispecific targeted PCR; NGS-16S, next-generation sequencing of 16S rRNA amplicons; PCR-16S, PCR of 16S rRNA gene followed by Sanger sequencing–based species identification.

Figure 1. Flow diagram showing clinical specimens included in the analysis in study of Bartonella spp. infections identified by molecular methods during 2003–2021 at an academic laboratory in the United States. If a patient had multiple specimens submitted >30 days apart, only information from the first Bartonella-positive specimen was included. Clinical specimens were tested for Bartonella spp. by PCR. A total of 430 specimens from 420 patients were included in the study. BT-PCR, B. henselae and B. quintana bispecific targeted PCR; NGS-16S, next-generation sequencing of 16S rRNA amplicons; PCR-16S, PCR of 16S rRNA gene followed by Sanger sequencing–based species identification.

Main Article

1These senior authors contributed equally to this article.

David W. McCormick, MD, MPH; Sara L. Rassoulian-Barrett, MS; Daniel R. Hoogestraat, BS, MB(ASCP); Stephen J. Salipante, MD, PhD; Dhruba SenGupta, PhD; Elizabeth A. Dietrich, PhD; Brad T. Cookson, MD, PhD; Grace E. Marx, MD, MPH; Joshua A. Lieberman, MD, PhD.

Page created: February 23, 2023
Page updated: February 23, 2023
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The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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