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Volume 29, Number 3—March 2023
Research Letter

Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

Hanna VauhkonenComments to Author , Hannimari Kallio-Kokko, Eija Hiltunen-Back, Lasse Lönnqvist, Jaana Leppäaho-Lakka, Laura Mannonen, Ravi Kant, Tarja Sironen, Satu Kurkela, Maija Lappalainen, Tomaž Mark Zorec, Samo Zakotnik, Doroteja Vlaj, Miša Korva, Tatjana Avšič-Županc, Mario Poljak, Teemu Smura, and Olli VapalahtiComments to Author 
Author affiliations: University of Helsinki, Helsinki, Finland (H. Vauhkonen, R. Kant, T. Sironen, T. Smura, O. Vapalahti); University of Helsinki and Helsinki University Hospital, Uusimaa, Finland (H. Kallio-Kokko, L. Mannonen, S. Kurkela, M. Lappalainen, T. Smura, O. Vapalahti); University of Helsinki and Helsinki University Hospital, Helsinki (E. Hiltunen-Back, L. Lönnqvist); Hospital Nova of Central Finland, Helsinki (J. Leppäaho-Lakka); University of Ljubljana, Ljubljana, Slovenia (T.M. Zorec, S. Zakotnik, D. Vlaj, M. Korva, T. Avšič-Županc, M. Poljak)

Main Article


Patient data from study of intrahost viral genome variation from 4 patients with early monkeypox virus infection, Finland, 2022*

Patient no.
Age, y
Onset of symptoms
May 19
May 21
Jun 1
Jun 13
Systemic signs/symptoms
Fever, enlarged inguinal lymph nodes
Fever, headache, exhaustion, enlarged inguinal lymph nodes
Fever, myalgia, lymphadenopathy, nausea, myalgia
Fever, headache, anal itch
Lesion sites
Penis, neck, trunk, face
Trunk, hands, feet, anus
Perianal skin
Evolution of lesions
Swab sample lesion sites (Cq value)
Penis (19.77)
Face (26.29), trunk (31.94)
Hand (33.38)
Perianal skin (23.4)
Monkeypox virus sequence†
ON782022 (face)
Sample date May 24, D5 May 31, D10 Jun 5, D4 Jun 16, D3

*All 4 patients were men who have sex with men who had recent sexual exposure and who had traveled to southern Europe. Cq value, quantitative cycle value of diagnostic orthopoxvirus PCR (Appendix); D, day after first symptom onset; NA, not available. †GenBank accession numbers. ‡Majority sequence.

Main Article

Page created: January 12, 2023
Page updated: February 20, 2023
Page reviewed: February 20, 2023
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