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Volume 29, Number 3—March 2023
Research Letter

Intrahost Monkeypox Virus Genome Variation in Patient with Early Infection, Finland, 2022

Hanna VauhkonenComments to Author , Hannimari Kallio-Kokko, Eija Hiltunen-Back, Lasse Lönnqvist, Jaana Leppäaho-Lakka, Laura Mannonen, Ravi Kant, Tarja Sironen, Satu Kurkela, Maija Lappalainen, Tomaž Mark Zorec, Samo Zakotnik, Doroteja Vlaj, Miša Korva, Tatjana Avšič-Županc, Mario Poljak, Teemu Smura, and Olli VapalahtiComments to Author 
Author affiliations: University of Helsinki, Helsinki, Finland (H. Vauhkonen, R. Kant, T. Sironen, T. Smura, O. Vapalahti); University of Helsinki and Helsinki University Hospital, Uusimaa, Finland (H. Kallio-Kokko, L. Mannonen, S. Kurkela, M. Lappalainen, T. Smura, O. Vapalahti); University of Helsinki and Helsinki University Hospital, Helsinki (E. Hiltunen-Back, L. Lönnqvist); Hospital Nova of Central Finland, Helsinki (J. Leppäaho-Lakka); University of Ljubljana, Ljubljana, Slovenia (T.M. Zorec, S. Zakotnik, D. Vlaj, M. Korva, T. Avšič-Županc, M. Poljak)

Main Article

Table

Patient data from study of intrahost viral genome variation from 4 patients with early monkeypox virus infection, Finland, 2022*

Data
 Patient no.
1
 2
 3
 4
Age, y
 30s
 20s
 30s
 30s
Onset of symptoms
 May 19
 May 21
 Jun 1
 Jun 13
Systemic signs/symptoms
 Fever, enlarged inguinal lymph nodes
 Fever, headache, exhaustion, enlarged inguinal lymph nodes
 Fever, myalgia, lymphadenopathy, nausea, myalgia
 Fever, headache, anal itch
Lesion sites
 Penis
 Penis, neck, trunk, face
 Trunk, hands, feet, anus
 Perianal skin
Evolution of lesions
 Synchronous
 Asynchronous
 Asynchronous
 Synchronous
Swab sample lesion sites (Cq value)
 Penis (19.77)
 Face (26.29), trunk (31.94)
 Hand (33.38)
 Perianal skin (23.4)
Monkeypox virus sequence†
 ON782021‡
 ON782022 (face)
 NA
 ON959143
Sample date May 24, D5 May 31, D10 Jun 5, D4 Jun 16, D3

*All 4 patients were men who have sex with men who had recent sexual exposure and who had traveled to southern Europe. Cq value, quantitative cycle value of diagnostic orthopoxvirus PCR (Appendix); D, day after first symptom onset; NA, not available. †GenBank accession numbers. ‡Majority sequence.

Main Article

Page created: January 12, 2023
Page updated: February 20, 2023
Page reviewed: February 20, 2023
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