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Volume 29, Number 3—March 2023
Research Letter

Genomic Analysis of Early Monkeypox Virus Outbreak Strains, Washington, USA

Pavitra Roychoudhury1Comments to Author , Jaydee Sereewit1, Hong Xie, Ethan Nunley, Shah M. Bakhash, Nicole A.P. Lieberman, and Alexander L. Greninger
Author affiliations: University of Washington, Seattle, Washington, USA (P. Roychoudhury, J. Sereewit, H. Xie, E. Nunley, S.M. Bakhash, N.A.P. Lieberman, A.L. Greninger); Fred Hutchinson Cancer Research Center, Seattle (P. Roychoudhury, A.L. Greninger)

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Figure

Phylogenomic analysis of 109 early monkeypox virus outbreak strains, Washington, USA. A) Phylogenetic tree showing that all Washington sequences fall within the major outbreak lineage B.1. The many identical sequences suggest community transmission; distinct sublineages suggest multiple MPXV introductions into the state. Black triangles indicate sequences from multiple swabs from the same patient, which were available for 11 persons, patients P01–P11. Clades with >5 sequences were assigned a color for tips and branches, and have text labels for the major sublineages, B.1.1, B.1.2, and B.1.3. All other tips and smaller clades are indicated in gray. B) Single nucleotide polymorphisms from each sample in panel A arrayed across the MPXV genome. Colors correspond to lineage coloring in panel A. MPXV, monkeypox virus.

Figure. Phylogenomic analysis of 109 early monkeypox virus outbreak strains, Washington, USA. A) Phylogenetic tree showing that all Washington sequences fall within the major outbreak lineage B.1. The many identical sequences suggest community transmission; distinct sublineages suggest multiple MPXV introductions into the state. Black triangles indicate sequences from multiple swabs from the same patient, which were available for 11 persons, patients P01–P11. Clades with >5 sequences were assigned a color for tips and branches, and have text labels for the major sublineages, B.1.1, B.1.2, and B.1.3. All other tips and smaller clades are indicated in gray. B) Single nucleotide polymorphisms from each sample in panel A arrayed across the MPXV genome. Colors correspond to lineage coloring in panel A. MPXV, monkeypox virus.

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1These first authors contributed equally to this article.

Page created: February 02, 2023
Page updated: February 20, 2023
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