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Volume 29, Number 5—May 2023
Research

SARS-CoV-2 Seroprevalence Compared with Confirmed COVID-19 Cases among Children, Colorado, USA, May–July 2021

Shannon C. O’BrienComments to Author , Lyndsey D. Cole, Bernadette A. Albanese, Allison Mahon, Vijaya Knight, Nathan Williams, Rachel Severson, Alexis Burakoff, Nisha B. Alden, and Samuel R. Dominguez
Author affiliations: Colorado Department of Public Health and Environment, Denver, Colorado, USA (S.C. O’Brien, N. Williams, R. Severson, A. Burakoff, N.B. Alden); Children’s Hospital Colorado, Aurora, Colorado, USA (L.D. Cole, A. Mahon, V. Knight, S.R. Dominguez); Tri-County Health Department, Greenwood Village, Colorado, USA (B.A. Albanese)

Main Article

Table 3

Previously reported positive SARS-CoV-2 viral diagnostic testing, seropositive case ascertainment, and multiplication factors by racial/ethnic and age group among seropositive children, Colorado, May 12–July 13, 2021*

Group Previous positive result Case ascertainment, % (95% CI)† Case ascertainment prevalence ratio (95% CI) Multiplication factor‡
Total
 50
 16.4 (12.5–21.1)
 NA
 6
Race/ethnicity
Non-Hispanic White 19 26.4 (16.7–38.1) Referent 4
Hispanic all races 19 13.3 (8.2–20.0) 0.50 (0.28–0.89§ 8
Non-Hispanic Black 3 7.5 (1.6–20.4) 0.28 (0.09–0.90)§ 13
Non-Hispanic other 6 17.1 (6.6–33.7) 0.65 (0.28–1.48) 6
Unknown
 3
 21.4 (4.7–50.8)
 0.81 (0.28–2.38)
 5
Age, y
1–4 13 13.1 (7.2–21.4) Referent 8
5–11 21 21.9 (14.1–31.5) 1.67 (0.89–3.13) 5
12–17 16 14.7 (8.6–22.7) 1.12 (0.57–2.21) 7

*NA, not applicable. †Case ascertainment calculated as the number of previous positive tests among seropositive children divided by the total number of seropositive children. ‡Multiplication factor calculated as the number of seropositive cases divided by the number of previous positive tests, also known as the inverse of case ascertainment. §Statistically significant at p<0.05.

Main Article

1Preliminary results from this study were presented at the Council of State and Territorial Epidemiologists Conference; Louisville, Kentucky, USA; June 19–23, 2022.

Page created: March 27, 2023
Page updated: April 18, 2023
Page reviewed: April 18, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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