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Volume 29, Number 5—May 2023
Research

Misdiagnosis of Clostridioides difficile Infections by Standard-of-Care Specimen Collection and Testing among Hospitalized Adults, Louisville, Kentucky, USA, 2019–20201

Julio A. Ramirez2, Frederick J. AnguloComments to Author , Ruth M. Carrico2, Stephen Furmanek2, Senén Peña Oliva, Joann M. Zamparo, Elisa Gonzalez, Pingping Zhang, Leslie A. Wolf Parrish, Subathra Marimuthu, Michael W. Pride, Sharon Gray, Cátia S. Matos Ferreira3, Forest W. Arnold, Raul E. Istúriz, Nadia Minarovic, Jennifer C. Moïsi, and Luis Jodar
Author affiliations: University of Louisville, Louisville, Kentucky, USA (J.A. Ramirez, R.M. Carrico, S. Furmanek, S. Peña Oliva, L.A. Wolf Parrish, S. Marimuthu, F.W. Arnold); Pfizer Vaccines, Collegeville, Pennsylvania, USA (F.J. Angulo, J.M. Zamparo, E. Gonzalez, P. Zhang, S. Gray, C.S. Matos Ferreira, R.E. Istúriz, N. Minarovic, J.C. Moïsi, L. Jodar); Pfizer, Pearl River, New York, USA (M.W. Pride)

Main Article

Figure 1

Incident diarrhea cases and testing of stool specimens among inpatients ≥50 years of age in Louisville, Kentucky, USA, before the COVID-19 pause in study of misdiagnosis of CDI by SOC specimen collection and testing among hospitalized adults, October 14, 2019–April 11, 2020. CCNA, cell culture cytotoxicity neutralization assay; CDI, Clostridioides difficile infection; NAAT, nucleic acid amplification test; PMC, pseudomembranous colitis; QNS, quantity not sufficient; Quik Chek, C. Diff Quik Chek Complete (Alere Techlab, https://www.techlab.com); SOC, standard-of-care.

Figure 1. Incident diarrhea cases and testing of stool specimens among inpatients ≥50 years of age in Louisville, Kentucky, USA, before the COVID-19 pause in study of misdiagnosis of CDI by SOC specimen collection and testing among hospitalized adults, October 14, 2019–April 11, 2020. CCNA, cell culture cytotoxicity neutralization assay; CDI, Clostridioides difficile infection; NAAT, nucleic acid amplification test; PMC, pseudomembranous colitis; QNS, quantity not sufficient; Quik Chek, C. Diff Quik Chek Complete (Alere Techlab, https://www.techlab.com); SOC, standard-of-care.

Main Article

1Study results were presented at the annual Anaerobe 2022 Congress, July 28–31, 2022, Seattle, Washington, USA.

2Current affiliation: Norton Healthcare, Louisville, Kentucky, USA.

3Current affiliation: AstraZeneca Pharmaceuticals, Wilmington, Delaware, USA.

Page created: March 10, 2023
Page updated: April 18, 2023
Page reviewed: April 18, 2023
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