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Volume 29, Number 5—May 2023
Dispatch

Limited Nosocomial Transmission of Drug-Resistant Tuberculosis, Moldova

Ecaterina Noroc1, Dumitru Chesov1, Matthias Merker1, Matthias I. Gröschel, Ivan Barilar, Viola Dreyer, Nelly Ciobanu, Maja Reimann, Valeriu Crudu, and Christoph LangeComments to Author 
Author affiliations: Chiril Draganiuc Phthisiopneumology Institute, Chisinau, Moldova (E. Noroc, N. Ciobanu, V. Crudu); Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau (D. Chesov); Research Center Borstel, Borstel, Germany (D. Chesov, M. Merker, I. Barilar, V. Dreyer, M. Reimann, C. Lange); German Center for Infection Research (DZIF), Borstel (M. Merker, I. Barilar, V. Dreyer, M. Reimann, C. Lange); Harvard Medical School, Boston, Massachusetts, USA (M.I. Gröschel); Charité–Universitätsmedizin Berlin, Berlin, Germany (M.I. Gröschel); University of Lübeck, Lübeck, Germany (M. Reimann, C. Lange); Baylor College of Medicine and Texas Children’s Hospital, Houston, Texas, USA (C. Lange)

Main Article

Figure 1

Maximum-likelihood phylogeny of 268 MDR TB isolates in study of limited nosocomial transmission of drug-resistant tuberculosis, Moldova. In outside circle, gray squares represent patient isolates with a maximum genetic distance of 5 single-nucleotide polymorphisms as a surrogate for recent transmission; pink squares indicate focus patients who acquired a new MDR MTBC strain during earlier treatment for drug-susceptible TB. Scale bar indicates number of substitutions per site. MDR, multidrug-resistant; MTBC, Mycobacterium tuberculosis complex; SNP, single-nucleotide polymorphism; TB, tuberculosis.

Figure 1. Maximum-likelihood phylogeny of 268 MDR TB isolates in study of limited nosocomial transmission of drug-resistant tuberculosis, Moldova. In outside circle, gray squares represent patient isolates with a maximum genetic distance of 5 single-nucleotide polymorphisms as a surrogate for recent transmission; pink squares indicate focus patients who acquired a new MDR MTBC strain during earlier treatment for drug-susceptible TB. Scale bar indicates number of substitutions per site. MDR, multidrug-resistant; MTBC, Mycobacterium tuberculosis complex; SNP, single-nucleotide polymorphism; TB, tuberculosis.

Main Article

1These first authors contributed equally to this article.

Page created: March 17, 2023
Page updated: April 19, 2023
Page reviewed: April 19, 2023
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