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Volume 29, Number 6—June 2023
Research Letter

Microscopic Evidence of Malaria Infection in Visceral Tissue from Medici Family, Italy

Frank Maixner, Dennis Drescher, Giulia Boccalini, Dario Piombino-Mascali, Marek Janko, Nicole Berens-Riha, Bum Jin Kim, Michelle Gamble, Jolanthe Schatterny, Rory E. Morty, Melanie Ludwig, Ben Krause-Kyora, Robert Stark, Hyun Joo An, Jens Neumann, Giovanna Cipollini, Rudolf Grimm, Nicole Kilian, and Albert ZinkComments to Author 
Author affiliations: Eurac Research, Bolzano, Italy (F. Maixner, G. Boccalini, G. Cipollini, A. Zink); University Hospital Heidelberg, Heidelberg, Germany (D. Drescher, J. Schatterny, R.E. Morty, M. Ludwig, N. Kilian); Vilnius University, Vilnius, Lithuania (D. Piombino-Mascali); Technical University of Darmstadt, Darmstadt, Germany (M. Janko, R. Stark); Institute of Tropical Medicine, Antwerp, Belgium (N. Berens-Riha); University of Munich, Munich, Germany (N. Berens-Riha); Oregon State University, Corvallis, Oregon, USA (B.J. Kim); Chungnam National University, Daejeon, Korea (B.J. Kim, H.J. An); Heritage and Archaeological Research Practice, Edinburgh, Scotland, UK (M. Gamble); Kiel University, Kiel, Germany (B. Krause-Kyora); Ludwig Maximilian University, Munich (J. Neumann); Agilent Technologies, Santa Clara, California, USA (R. Grimm)

Main Article

Figure

Microscopic analysis of malaria infection in visceral tissue from Medici family, Italy. We evaluated a 2.5 cm × 1.5 cm tissue piece (ID 1297) from 1 jar containing viscera of a Medici family member and identified a potential blood vessel containing erythrocytes. A) Histological cross section of the tissue stained with hematoxylin and eosin; scale bar indicates 200 µm. Inset shows a possible erythrocyte; scale bar indicates 3 µm. B) Giemsa staining of a paraffin section of viscera suggesting the presence of parasites within the erythrocytes. Scale bar indicates 50 µm. C) Atomic force microscopy (AFM) of the tissue section. An optical microscope was used to define appropriate sample areas for AFM imaging (left image); scale bar indicates 20 µm. Enlarged area at right shows a ring stage of Plasmodium falciparum in an erythrocyte; scale bar indicates 2 µm.

Figure. Microscopic analysis of malaria infection in visceral tissue from Medici family, Italy. We evaluated a 2.5 cm × 1.5 cm tissue piece (ID 1297) from 1 jar containing viscera of a Medici family member and identified a potential blood vessel containing erythrocytes. A) Histological cross section of the tissue stained with hematoxylin and eosin; scale bar indicates 200 µm. Inset shows a possible erythrocyte; scale bar indicates 3 µm. B) Giemsa staining of a paraffin section of viscera suggesting the presence of parasites within the erythrocytes. Scale bar indicates 50 µm. C) Atomic force microscopy (AFM) of the tissue section. An optical microscope was used to define appropriate sample areas for AFM imaging (left image); scale bar indicates 20 µm. Enlarged area at right shows a ring stage of Plasmodium falciparum in an erythrocyte; scale bar indicates 2 µm.

Main Article

Page created: April 12, 2023
Page updated: May 18, 2023
Page reviewed: May 18, 2023
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