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Volume 29, Number 7—July 2023
Dispatch

Candida vulturna Outbreak Caused by Cluster of Multidrug-Resistant Strains, China

Han Du1, Jian Bing1, Xiaohong Xu1, Qiushi Zheng, Tianren Hu, Yajuan Hao, Shuping Li, Clarissa J. Nobile, Ping Zhan2Comments to Author , and Guanghua Huang2Comments to Author 
Author affiliations: Huashan Hospital, Fudan University, Shanghai, China (H. Du, J. Bing, Q. Zheng, T. Hu, G. Huang); Sinopharm Tongmei General Hospital, Datong, China (X. Xu, Y. Hao, S. Li); University of California, Merced, California, USA (C.J. Nobile); Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China (P. Zhan)

Main Article

Figure 1

Maximum-likelihood phylogeny analysis of Candida vulturna strains from 19 infected patients in Shanxi Province, China, January 1, 2019–October 26, 2022, based on multilocus sequence typing (MLST). Eight genes (AAT1, ACC1, ADP1, ALA1, ERG11, RPB1, RPB2, and ZWF1) were concatenated and used for phylogenetic analyses. The tree was generated using the program RAxML (https://cme.h-its.org/exelixis/web/software/raxml). The general time reversible model, gamma distribution, 1,000 bootstraps, and midpoint root were adopted. Bold text indicates strains isolated in this study; reference strain data from whole-genome sequencing is from the National Center for Biotechnology Information gene database (accession nos. SRR11091965–67, SRR11092032, SRR11092036, SRR22996287). Sequences for strain CBS14366 were retrieved from its genomic assembly (GenBank accession no. GCA_026585945.1). Strains CVDH01-CVDH19 were isolated from patients of C. vulturna infection (cases C1–C19; Table; Appendix Figure 1). Scale bar indicates substitutions per site.

Figure 1. Maximum-likelihood phylogeny analysis of Candida vulturna strains from 19 infected patients in Shanxi Province, China, January 1, 2019–October 26, 2022, based on multilocus sequence typing (MLST). Eight genes (AAT1, ACC1, ADP1, ALA1, ERG11, RPB1, RPB2, and ZWF1) were concatenated and used for phylogenetic analyses. The tree was generated using the program RAxML (https://cme.h-its.org/exelixis/web/software/raxml). The general time reversible model, gamma distribution, 1,000 bootstraps, and midpoint root were adopted. Bold text indicates strains isolated in this study; reference strain data from whole-genome sequencing is from the National Center for Biotechnology Information gene database (accession nos. SRR11091965–67, SRR11092032, SRR11092036, SRR22996287). Sequences for strain CBS14366 were retrieved from its genomic assembly (GenBank accession no. GCA_026585945.1). Strains CVDH01-CVDH19 were isolated from patients of C. vulturna infection (cases C1–C19; Table; Appendix Figure 1). Scale bar indicates substitutions per site.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: May 22, 2023
Page updated: June 21, 2023
Page reviewed: June 21, 2023
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