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Volume 29, Number 8—August 2023
Research Letter

Fatal Meningitis from Shiga Toxin–Producing Escherichia coli in 2 Full-Term Neonates, France

Guillaume GeslainComments to Author , Aurélie Cointe, Philippe Bidet, Céline Courroux, Soumeth Abasse, Patricia Mariani, and Stéphane Bonacorsi
Author affiliations: Robert Debré University Hospital Assistance Publique-Hôpitaux de Paris, Paris, France (G. Geslain, A. Cointe, P. Bidet, C. Courroux, P. Mariani, S. Bonacorsi); Université Paris Cité INSERM, Paris (G. Geslain, A. Cointe, P. Bidet, S. Bonacorsi); Mayotte Hospital, Mamoudzou, Mayotte Island, France (S. Abasse)

Main Article

Table

Genes encoding confirmed or putative virulence factors found in Shiga toxin–producing Escherichia coli ST504 strains that caused fatal meningitis in 2 full-term neonates, France*

Gene Gene function E. coli O117:H7 E. coli O156:H7
iucC Aerobactin biosynthesis Positive Negative
iutA Aerobactin receptor Positive Negative
fyuA Yersiniabactin receptor Positive Positive
irp2 Yersiniabactin biosynthesis Positive Positive
iroN Salmochelin receptor Positive Positive
iroD Salmochelin biosynthesis Positive Positive
chuA Hemin uptake Negative Positive
cvaA Colicin V Negative Positive
iss Increased serum survival protein Positive Negative
sitA Iron transport protein Positive Positive
ibeA Invasin Negative Positive
vat Vacuolating autotransporter toxin Negative Positive
ihA-like Putative Iha-like adhesin Positive Positive
mchB Microcin Positive Positive
mchC Microcin Negative Positive
mchF Microcin Negative Positive
mcmA Microcin Negative Positive
gad Glutamate decarboxylase Positive Positive
iha Adherence protein Positive Positive
capU Hexosyltransferase homologue protein Positive Positive
sigA Serine protease autotransporter Positive Positive
stx1A-a Shiga toxin 1 variant a subunit A Positive Positive
stx1B-a Shiga toxin 1 variant a subunit B Positive Positive
kpsF Polysialic acid group 2 capsule expression protein Positive Positive
kpsD Translocation of capsule of groups 2 and 3 Positive Positive
neuC K1 capsular antigen Positive Positive

*E. coli serotypes were O117:H7 (case 1, 8-day-old boy) and O156:H7 (case 2, 4-day-old boy). ST, sequence type.

Main Article

Page created: June 06, 2023
Page updated: July 20, 2023
Page reviewed: July 20, 2023
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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