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Volume 3, Number 2—June 1997
THEME ISSUE
From the 1st International Conference on Emerging Zoonoses
From the 1st International Conference on Emerging Zoonoses

Brucellosis: an Overview

Michael J. Corbel
Author affiliation: National Institute of Biological Standards and Control, Hertfordshire, United Kingdom

Main Article

Table 1

Brucellosis in animals, Europe, 1994

Bovine Ovine/caprine Porcine Ovine
Country (B. abortus) (B. melitensis) (B. suis) (B. ovis)
Albania - + + +
Belgium + - - -
Bulgaria - - + +
Croatia - - + +
Czech - - ? -
Republic
France + ++ ? +
Germany + - ? +
Greece + ++ ND ND
Ireland + - - -
Italy + + - ND
Latvia - - + -
Lithuania - - - ?
Macedonia + + - -
Malta + + - -
Poland + + ? -
Portugal + + - +
Romania - - + -
Russia ++ ++ + +
Slovakia - - ND -
Slovenia - - - +
Spain + + - +
Ukraine ND ND ND ND
Yugoslavia + + + -

- not present
+ low sporadic incidence
++ high incidence
? presence uncertain
ND no data
None of the four types of brucellosis is present in Austria, Denmark, Estonia, Finland, Hungary, Iceland, Luxembourg, Moldavia, Netherlands, Sweden, Switzerland, and the United Kingdom
Source for Tables 1-8: FAO-WHO-OIE Animal Health Yearbooks, 1994, 1995.

Main Article

References
  1. Amato Gauci  AJ. The return of brucellosis. Maltese Medical Journal. 1995;7:7–8.
  2. Garcia Carrillo  C. Animal and human brucellosis in the Americas. Paris: OIE, 1990: 287.
  3. Lopez Merino  A. Brucellosis in Latin America. Young EJ, Corbel MH, editors. Brucellosis; clinical and laboratory aspects. Boca Raton: CRC Press Inc., 1989:151-61.
  4. Mantur  BG, Mangalgi  SS, Mulimani  B. Brucella melitensis-a sexually transmissible agent. Lancet. 1996;347:1763. DOIPubMedGoogle Scholar
  5. Tessaro  SV, Forbes  LB. Brucella suis biotype 4; a case of granulomatous nephritis in a barren ground caribou (Rangifer tarandus groenlandicus L) with a review of the distribution of rangiferine brucellosis in Canada. J Wildl Dis. 1986;22:479–88.PubMedGoogle Scholar
  6. Carmichael  LE. Brucella canis. In: Nielsen K, Duncan JR, editors. Animal brucellosis. Boca Raton: CRC Press Inc.: 1990,335-50.
  7. Ross  HM, Foster  G, Reid  RJ, Jabans  KL, MacMillan  AP. Brucella species infection in sea mammals. Vet Rec. 1994;132:359.
  8. Ewalt  DR, Payeur  JB, Martin  BM, Cummins  DR, Miller  WG. Characteristics of a Brucella species from a bottlenose dolphin (Tursiops truncatus). J Vet Diagn Invest. 1994;6:448–52.PubMedGoogle Scholar
  9. De Ley  J, Mannheim  W, Segers  P, Lievens  A. Ribosomal ribonucleic acid cistron similarities and taxonomic neighbourhood of Brucella and CDC Group Vd. Int J Syst Bacteriol. 1987;37:35–42. DOIGoogle Scholar
  10. Verger  JM, Grimont  F, Grimont  PAD, Grayon  M. Brucella A monospecific genus as shown by deoxyribonucleic acid hybridization. Int J Syst Bacteriol. 1985;35:292–5. DOIGoogle Scholar
  11. Alton  GG, Jones  LM, Pietz  DE. Laboratory techniques in brucellosis. Geneva: World Health Organization 1975.
  12. Corbel  MJ, Morgan  WJB. Genus Brucella Meyer and Shaw 1920, 173 AL. In: Holt JG, editor. Bergey's manual of systematic bacteriology vol. 1. Baltimore (MD): Williams and Wilkins, 1984:377-88.
  13. Corbel  MJ. Identification of dye-sensitive strains of Brucella melitensis. J Clin Microbiol. 1991;29:1066–8.PubMedGoogle Scholar
  14. Corbel  MJ, Thomas  EL. Use of phage for the identification of Brucella canis and Brucella ovis cultures. Res Vet Sci. 1985;35:35–40.
  15. Banai  M, Mayer  I, Cohen  A. Isolation, identification and characterization in Israel of Brucella melitensis biovar 1 atypical strains susceptible to dyes and penicillin, indication of the evolution of a new variant. J Clin Microbiol. 1990;28:1057–9.PubMedGoogle Scholar
  16. Allardet-Servent  A, Bourg  G, Ramuz  M, Bellis  M, Roizes  G. DNA polymorphism in strains of the genus Brucella. J Bacteriol. 1988;170:4603–7.PubMedGoogle Scholar
  17. O'Hara  MJ, Collins  DM, Lisle  GW. Restriction endonuclease analysis of Brucella ovis and other Brucella species. Vet Microbiol. 1985;10:425–9. DOIPubMedGoogle Scholar
  18. Ficht  TA, Bearden  SW, Sowa  BA, Adams  LG. DNA sequence and expression of the 36-kilodalton outer membrane protein gene of Brucella abortus. Infect Immun. 1989;57:3281–91.PubMedGoogle Scholar
  19. Cellier  MFM, Teyssier  J, Nicolas  M, Liautard  JB, Marti  J. SriWidada J. Cloning and characterization of the Brucella ovis heat shock protein DnaK functionally expressed in Escherichia coli. J Bacteriol. 1992;174:8036–42.PubMedGoogle Scholar
  20. Sangari  FJ, García-Lobo  JM, Aguero  J. The Brucella abortus vaccine strain B19 carries a deletion in the erythritol catabolic genes. FEMS Microbiol Lett. 1994;121:337–42. DOIPubMedGoogle Scholar
  21. Douglas  JT, Rosenberg  EY, Nikaido  H, Verstreate  DR, Winter  AJ. Porins of Brucella species. Infect Immun. 1984;44:16–21.PubMedGoogle Scholar
  22. Ficht  TA, Husseinen  HS, Derr  J, Bearden  SW. Species-specific sequences at the omp2 locus of Brucella type strains. Int J Syst Bacteriol. 1996;46:329–31. DOIPubMedGoogle Scholar
  23. Cloeckaert  A, Verger  J-M, Grayon  M, Grepinet  O. Restriction site polymorphism of the genes encoding the major 25kDa and 36kDa outer membrane proteins of Brucella. Microbiology. 1995;141:2111–21. DOIPubMedGoogle Scholar
  24. Cloeckaert  A, Salih-Alj Debarrh  H, Zygmunt  MS, Dubray  G. Polymorphism at the dnak locus of Brucella species and identification of a Brucella melitensis species-specific marker. J Med Microbiol. 1996;45:200–13. DOIPubMedGoogle Scholar
  25. Michaux  S, Paillisson  J, Carles-Nurit  MJ, Bourg  G, Allardet Servent  A, Ramuz  M. Presence of two independent chromosomes in the Brucella melitensis 16M genome. J Bacteriol. 1993;175:701–5.PubMedGoogle Scholar
  26. Jumas-Bitlak  E, Maugard  C, Michaux-Charachon  S, Allardet-Servent  A, Perrin  A, O'Callaghan  D. Study of the organization of the genomes of Escherichia coli, Brucella melitensis and Agrobacterium tumefaciens by insertion of a unique restriction site. Microbiology. 1995;141:2425–32. DOIPubMedGoogle Scholar
  27. Rigby  CE, Fraser  ADE. Plasmid transfer and plasmid-mediated genetic exchange in Brucella abortus. Can J Vet Res. 1989;53:326–30.PubMedGoogle Scholar
  28. Cieslak  TJ, Robb  ML, Drabick  CJ, Fisher  GW. Catheter-associated sepsis caused by Ochrobactrum anthropi: report of a case and review of related non-fermentative bacteria. Clin Infect Dis. 1992;14:902–7.PubMedGoogle Scholar
  29. Da Costa  M, Guillou  J-P, Garin-Bastuji  B. ThiJbaud M, Dubray G. Specificity of six gene sequences for the detection of the genus Brucella by DNA amplification. J Appl Bacteriol. 1996;81:267–75.PubMedGoogle Scholar
  30. Minnick  MF, Stiegler  GL. Nucleotide sequence and comparison of the 5S ribosomal genes of Rochalimaea henselae, R. quintana and Brucella abortus. Nucleic Acids Res. 1993;21:2518. DOIPubMedGoogle Scholar
  31. Relman  DA, Lepp  PW, Sadler  KN, Schmidt  TM. Phylogenetic relationships among the agent of bacillary angiomatosis, Bartonella bacilliformis, and other alpha-proteobacteria. Mol Microbiol. 1992;6:1801–7. DOIPubMedGoogle Scholar
  32. Perry  MB, Bundle  DR. Lipopolysaccharide antigens and carbohydrates of Brucella. In: Adams LG, editor. Advances in Brucellosis Research Austin (TX): Texas A & M University, 1990;76-88.
  33. Bundle  DR, Cherwonogrodzky  JW, Gidney  MAJ, Meikle  PJ, Perry  MB, Peters  T. Definition of Brucella A and M epitopes by monoclonal typing reagents and synthetic oligosaccharides. Infect Immun. 1989;57:2829–36.PubMedGoogle Scholar
  34. Wilson  GS, Miles  AA. The serological differentiation of smooth strains of the Brucella group. Br J Exp Pathol. 1932;13:1–13.
  35. Goldbaum  FA, Leoni  J, Walach  JC, Fossati  CA. Characterisation of an 18-kilodalton Brucella cytoplasmic protein which appears to be a serological marker of active infection of both human and bovine brucellosis. J Clin Microbiol. 1993;31:2141–5.PubMedGoogle Scholar
  36. Goldbaum  FA, Morelli  L, Wallach  J, Rubbi  CP, Fossati  CA. Human brucellosis: immunoblotting analysis of three Brucella abortus antigenic fractions allows the detection of components of diagnostic importance. Medicina (B Aires). 1991;51:227–32.PubMedGoogle Scholar
  37. Corbel  MJ. The immunogenic activity of ribosomal fractions derived from Brucella abortus. Journal of Hygiene, Cambridge. 1976;76:65–74. DOIGoogle Scholar
  38. Bachrach  G, Banai  M, Bardenstein  S, Hoida  G, Genizi  A, Bercovier  H. Brucella ribosomal protein L7 / L12 is a major component in the antigenicity of Brucellin INRA for delayed hypersensitivity in Brucella-sensitized guinea- pigs. Infect Immun. 1994;62:5361–6.PubMedGoogle Scholar
  39. Oliveira  S, Splitter  GA. Immunization of mice with recombinant L7 / L12 ribosomal protein confers protection against Brucella abortus infection. Vaccine. 1996;14:959–62. DOIPubMedGoogle Scholar
  40. Zhan  Y, Cheers  C. Differential activation of Brucella-reactive CD4+ cells by Brucella infection or immuni-zation with antigenic extracts. Infect Immun. 1995;63:969–95.PubMedGoogle Scholar
  41. Caron  E, Peyrard  T, Kohler  S, Cabane  S, Liautard  J-P, Dornand  J. Live Brucella spp. fail to induce tumour necrosis factor alpha excretion upon infection of U937-derived phagocytes. Infect Immun. 1994;62:5267–74.PubMedGoogle Scholar
  42. Dubray  G. Protective antigens in brucellosis. Ann Inst Pasteur Microbiol. 1987;138:84–7. DOIPubMedGoogle Scholar
  43. Canning  PC, Roth  JA, Deyoe  BL. Release of 5'-guanosine monophosphate and adenine by Brucella abortus and the intracellular survival of the bacteria. J Infect Dis. 1986;154:464–70.PubMedGoogle Scholar
  44. Bricker  BJ, Tabatabai  LB, Judge  BA, Deyoe  BL, Mayfield  JE. Cloning, expression and occurrence of the Brucella Cu-Zn dismutase. Infect Immun. 1990;58:2933–9.
  45. Lin  J, Ficht  TA. Protein synthesis in Brucella abortus induced during macrophage infection. Infect Immun. 1995;63:1409–14.PubMedGoogle Scholar
  46. Tatum  FM, Cheville  NF, Morfitt  D. Cloning, charac-terisation and construction of htr A and htr A - like mutants of Brucella abortus and their survival in BALB/C mice. Microb Pathog. 1994;17:23–36. DOIPubMedGoogle Scholar
  47. Tatum  FM, Morfitt  DC, Halling  SM. Construction of a Brucella abortus Rec A mutant and its survival in mice. Microb Pathog. 1993;14:177–85. DOIPubMedGoogle Scholar
  48. Santini  C, Baiocchi  P, Berardelli  A, Venditti  M, Serra  P. A case of brain abscess due to Brucella melitensis. Clin Infect Dis. 1994;19:977–8.PubMedGoogle Scholar
  49. Potasman  I, Even  L, Banai  M, Cohen  E, Angel  D, Jaffe  M. Brucellosis: an unusual diagnosis for a seronegative patient with abscesses, osteomyelitis and ulcerative colitis. Rev Clin Dis. 1991;13:1039–42.
  50. Shakir  RA, Al-Din  ASN, Araj  GF, Lulu  AR, Mousa  AR, Saadah  MA. Clinical diagnosis of neurobrucellosis. A report on 19 cases. Brain. 1987;110:213–23. DOIPubMedGoogle Scholar
  51. Young  EJ. An overview of human brucellosis. Clin Infect Dis. 1995;21:283–90.PubMedGoogle Scholar
  52. Madkour  MM. Brucellosis. Butterworths, London 1989.
  53. Kolman  S, Maayan  MC, Gotesman  G, Roszenstain  LA, Wolach  B, Lang  R. Comparison of the Bactec and lysis concentration method for the recovery of Brucella species from clinical specimens. Eur J Clin Microbiol Infect Dis. 1991;10:647–8. DOIPubMedGoogle Scholar
  54. Solomon  HM, Jackson  D. Rapid diagnosis of Brucella melitensis in blood; some operational characteristics of the BACT / ALERT. J Clin Microbiol. 1992;28:2139–41.
  55. Luzzi  GA, Brindle  R, Socket  PN, Solera  J, Klenerman  P, Warrell  DA. Brucellosis: imported and laboratory-acquired cases, and an overview of treatment trials. Trans R Soc Trop Med Hyg. 1993;87:138–41. DOIPubMedGoogle Scholar
  56. Matar  FM, Khreissir  IA, Abdonoor  AM. Rapid laboratory confirmation of human brucellosis by PCR analysis of a target sequence on the 31-kilodalton Brucella antigen DNA. J Clin Microbiol. 1996;34:477–8.PubMedGoogle Scholar
  57. Araj  GF, Lulu  AR, Mustafa  MY, Khateeb  MI. Evaluation of ELISA in the diagnosis of acute and chronic brucellosis in human beings. Journal of Hygiene, Cambridge. 1986;97:457–69. DOIGoogle Scholar
  58. Ariza  J, Pellicer  T, Pallarés  R, Foz  A, Gudiol  F. Specific antibody profile in human brucellosis. Clin Infect Dis. 1992;14:131–40.PubMedGoogle Scholar
  59. Joint  FAO, Expert  WHO. Committee on Brucellosis. Sixth Report. World Health Organ Tech Rep Ser No. 740. Geneva: World Health Organization, 1986.
  60. Ariza  J, Gudiol  F, Pallarés  R, Rufi  G, Fernàndez-Viladrich  P. Comparative trial of rifampicin-doxycycline versus tetracycline-streptomycin in the therapy of human brucellosis. Antimicrob Agents Chemother. 1985;28:548–51.PubMedGoogle Scholar
  61. Akova  M, Uzun  O, Akalin  HE, Hayran  M, Unal  S, Gur  D. Quinolones in the treatment of human brucellosis; comparative trial of ofloxacin-rifampin versus doxycycline- rifampin. J Antimicrob Chemother. 1993;37:1831–4.
  62. Shakir  RA. Postgrad Med J. 1986;62:1077–9.Neurobrucellosis DOIPubMedGoogle Scholar
  63. Khuri-Bulos  NA, Daoud  AH, Azab  SM. Treatment of childhood brucellosis: results of a prospective trail on 113 childred. Pediatr Infect Dis. 1993;12:377–81.
  64. Corbel  MJ. Vaccines against bacterial zoonoses. J Med Microbiol. 1997;46:267–9. DOIPubMedGoogle Scholar
  65. Crawford  RM, Van De Verg  L, Yuan  L, Hadfield  TL, Warren  RL, Drazek  ES, Deletion of purE attenuates Brucella melitensis infection in mice. Infect Immun. 1996;64:2188–92.PubMedGoogle Scholar
  66. Xie  X. Orally administered brucellosis vaccine Brucella suis strain 2 vaccine. Vaccine. 1986;4:212–6. DOIPubMedGoogle Scholar
  67. Mustafa  AA, Abusowa  M. Field-oriented trial of the Chinese Brucella suis strain 2 vaccine in sheep and goats in Libya. Annales de Recherche Veterinaire. 1993;24:422–9.
  68. Schurig  GG, Roop  RM, Bagchi  T, Boyle  S, Buhrman  D, Sriranganathan  N. Biological properties of RB51. A stable strain of Brucella abortus. Vet Microbiol. 1991;28:171–88. DOIPubMedGoogle Scholar

Main Article

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Page updated: December 21, 2010
Page reviewed: December 21, 2010
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