Dengue Virus Serotype 3 Origins and Genetic Dynamics, Jamaica
Shanice A. Redman
1, Lester J. Perez
1, Kenn Forberg, Keisha Francis, Jerome P. Walker, Tamara K. Thompson, Heather Phillips, Gavin A. Cloherty, Michael G. Berg, and Joshua J. Anzinger
Author affiliations: Abbott Pandemic Defense Coalition, Kingston, Jamaica (S.A. Redman, K. Francis, J.P. Walker, T.K. Thompson, H. Phillips, J.J. Anzinger); The University of the West Indies, Kingston (S.A. Redman, K. Francis, J.P. Walker, T.K. Thompson, H. Phillips, J.J. Anzinger); Abbott Laboratories, Abbott Park, Illinois, USA (L.J. Perez, K. Forberg, G.A. Cloherty, M.G. Berg); Abbott Pandemic Defense Coalition, Abbott Park (L.J. Perez, K. Forberg, G.A. Cloherty, M.G. Berg); Global Virus Network, Baltimore, Maryland, USA (J.J. Anzinger)
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Figure 3
Figure 3. Time-scaled phylogenetic analysis, molecular characterization, dynamics, and natural selection of dengue virus serotype 3 in Jamaica. A) Phylogenetic tree indicates monophyletic clusters of strains from Jamaica (bold text) extracted from the discrete phylogeographic analysis (Figure 2). Discrete sp values (ω) for nodes evaluated for episodic selection are shown. Full sp values for nodes are shown in Appendix Figure 2, panel B. B) Strains were evaluated for amino acid replacements according to each TG. Arrows indicate episodic selection of each main TG clade. Bold text indicates positively selected mutations. sp, state probability; TG, temporal group.
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