Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 30, Number 11—November 2024
Dispatch

Invasive Group A Streptococcus Hypervirulent M1UK Clone, Canada, 2018–2023

Alyssa R. GoldenComments to Author , Averil Griffith, Gregory J. Tyrrell, Julianne V. Kus, Allison McGeer, Marc-Christian Domingo, Jennifer Grant, Jessica Minion, Paul Van Caeseele, Guillaume Desnoyers, David Haldane, Yang Yu, Xiaofeng Ding, Laura Steven, Jan McFadzen, Courtney Primeau, and Irene Martin
Author affiliation: Public Health Agency of Canada, Winnipeg, Manitoba, Canada (A. Golden, A. Griffith, I. Martin); Provincial Laboratory for Public Health (Microbiology), Edmonton, Alberta, Canada (G.J. Tyrrell); Public Health Ontario, Toronto, Ontario, Canada (J.V. Kus); University of Toronto, Toronto (J.V. Kus); Mount Sinai Hospital, Toronto (A. McGeer); Institut National de Santé Publique du Québec, Sainte-Anne-de-Bellevue, Québec, Canada (M-.C. Domingo); British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada (J. Grant); Roy Romanow Provincial Laboratory, Regina, Saskatchewan, Canada (J. Minion); Cadham Provincial Laboratory, Winnipeg (P. Van Caeseele); Laboratoire de Santé Publique du New Brunswick, Moncton, New Brunswick, Canada (G. Desnoyers); Queen Elizabeth II Health Science Centre, Halifax, Nova Scotia, Canada (D. Haldane); Newfoundland and Labrador Public Health Laboratory, St. John’s, Newfoundland, Canada (Y. Yu); Queen Elizabeth Hospital, Charlottetown, Prince Edward Island, Canada (X. Ding); Stanton Territorial Hospital Laboratory, Yellowknife, Northwest Territories, Canada (L. Steven); Yukon Communicable Disease Control, Whitehorse, Yukon, Canada (J. McFadzen); Public Health Agency of Canada, Ottawa, Ontario, Canada (C. Primeau)

Main Article

Table

Characteristics of M1UK lineage and other invasive group A Streptococcus emm1 isolates collected in Canada, 2018–2023

Isolate feature* Lineage, no. (%) isolates
 p value‡
M1UK, n = 1,069 Other emm1, n = 1,246†
Antimicrobial susceptibility
Penicillin 100 100 1.000
Erythromycin 99.5 (1,064) 99.2 (1,236) 0.4375
Clindamycin 99.8 (1,067) 99.5 (1,240) 0.2997
Chloramphenicol 100 100 1.000
Levofloxacin 99.9 (1,068) 99.8 (1,243) 0.6291
Tetracycline
 99.6 (1,065)
 99.1 (1,235)
 0.1928
Toxin gene presence
speA 98.4 (1,052) 97.4 (1,214) 0.1124
speC 43.8 (468) 8.3 (103) <0.0001
speG 100 (1,069) 99.9 (1,245) 1.000
speH 0 0 1.000
speI 0 0 1.000
speJ 99.5 (1,064) 99.4 (1,238) 0.7817
speK 0.1 (1) 0 0.4618
speL 0 0 1.000
speM 0 0 1.000
smeZ 98.4 (1,052) 98.9 (1,232) 0.3674
ssa
 35.5 (379)
 4.4 (55)
 <0.0001
Virulence gene presence
Phage-associated DNase, spd1 43.9 (469) 8.3 (103) <0.0001
Phage-associated hyaluronidase, hylP
 37.8 (404)
 3.9 (49)
 <0.0001
Gene combinations
speC + ssa + spd1
 35.4 (378)
 8.3 (55)
 <0.0001
speC + spd1 8.3 (89) 3.9 (48) <0.0001

*All isolate features (antimicrobial susceptibilities, toxin, and virulence gene presence) were inferred from whole-genome sequences. †Other emm1 with whole-genome sequencing data available. ‡Two-tailed; p<0.05 considered significant.

Main Article

Page created: September 30, 2024
Page updated: October 22, 2024
Page reviewed: October 22, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external