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Volume 30, Number 12—December 2024
Dispatch

Umatilla Virus in Zoo-Dwelling Cape Penguins with Hepatitis, Germany

Monica Mirolo1, Madeleine de le Roi1, Katja von Dörnberg, Franziska Kaiser, Adnan Fayyad, Christina Puff, Ulrich Voigt, Ursula Siebert, Martin Ludlow, Wolfgang Baumgärtner, and Albert OsterhausComments to Author 
Author affiliation: University of Veterinary Medicine, Hannover Foundation, Hannover, Germany (M. Mirolo, M. de le Roi, F. Kaiser, A. Fayyad, C. Puff, U. Voigt, U. Siebert, M. Ludlow, W. Baumgärtner, A. Osterhaus); Hannover Adventure Zoo, Hannover (K. von Dörnberg); An-Najah National University, Nablus, Palestine (A. Fayyad)

Main Article

Figure

Histopathologic findings and fluorescence in situ hybridization (FISH) results in a deceased zoo-dwelling, Umatilla virus (UMAV)–infected penguin, Germany, 2019. A) Hematoxylin and eosin (H&E) stain of liver tissue shows mild, multifocal, randomly distributed, coagulative necrosis of hepatocytes (arrows) and mild-to-moderate, periportal, lymphocytic hepatitis (asterisk). B) FISH of liver tissue shows intracytoplasmically UMAV RNA-positive hepatocytes. C) H&E stain of spleen tissue shows no significant histopathologic alterations. D) FISH of spleen tissue shows multifocal cells within follicle centers, most likely macrophages, tested cytoplasmatically positive for UMAV RNA. E) H&E stain of small intestine tissue shows mild, multifocal necrosis of epithelial cells of the small intestine. F) FISH of small intestine tissue shows positive UMAV RNA signal within enterocytes. Inset: Multifocal, granular red signal within cytoplasm of enterocytes. Scale bars indicate 50 µm.

Figure. Histopathologic findings and fluorescence in situ hybridization (FISH) results in a deceased zoo-dwelling, Umatilla virus (UMAV)–infected penguin, Germany, 2019. A) Hematoxylin and eosin (H&E) stain of liver tissue shows mild, multifocal, randomly distributed, coagulative necrosis of hepatocytes (arrows) and mild-to-moderate, periportal, lymphocytic hepatitis (asterisk). B) FISH of liver tissue shows intracytoplasmically UMAV RNA-positive hepatocytes. C) H&E stain of spleen tissue shows no significant histopathologic alterations. D) FISH of spleen tissue shows multifocal cells within follicle centers, most likely macrophages, tested cytoplasmatically positive for UMAV RNA. E) H&E stain of small intestine tissue shows mild, multifocal necrosis of epithelial cells of the small intestine. F) FISH of small intestine tissue shows positive UMAV RNA signal within enterocytes. Inset: Multifocal, granular red signal within cytoplasm of enterocytes. Scale bars indicate 50 µm.

Main Article

1These authors contributed equally to this article.

Page created: October 25, 2024
Page updated: March 31, 2025
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