Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 30, Number 2—February 2024
Research Letter

Lymphocytic Choriomeningitis Virus Lineage V in Wood Mice, Germany

Calvin Mehl, Olayide Abraham Adeyemi, Claudia Wylezich1, Dirk Höper, Martin Beer, Cornelia Triebenbacher, Gerald Heckel, and Rainer G. UlrichComments to Author 
Author affiliations: Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany (C. Mehl, O.A. Adeyemi, C. Wylezich, D. Höper, M. Beer, R.G. Ulrich); German Center for Infection Research, Partner Site Hamburg-Lübeck-Borstel-Riems, Germany (C. Mehl, R.G. Ulrich); Bavarian State Institute for Forest and Forestry, Freising, Germany (C. Triebenbacher); University of Bern, Bern, Switzerland (G. Heckel)

Main Article

Figure

Phylogenetic analysis of the nucleocapsid protein encoding region of lymphocytic choriomeningitis virus lineage V identified in wood mice, Germany (boldface), and reference sequences. Bayesian inference method was used to analyze the 1,674-nt open reading frame corresponding to codons 1–558 without the stop codon. GenBank accession number, strain name, host species, and country of origin (if known) are shown. Roman numerals I–IV represent the different virus lineages as defined previously (10). Lunk virus from Mus minutoides mice was used as an outgroup. WE and Armstrong are laboratory strains of lymphocytic choriomeningitis virus. Scale bar indicates nucleotide substitutions per site. Asyl, Apodemus sylvaticus; AU, Australia; BG, Bulgaria; CN, China; CZ, Czech Republic; DE, Germany; ES, Spain; FR, France; GA, Gabon; GF, French Guiana; JP, Japan; Mm, Mus musculus; Mmm, M. musculus musculus; Mmd, M. musculus domesticus; SK, Slovakia; US, United States; YU, former Yugoslavia.

Figure. Phylogenetic analysis of the nucleocapsid protein encoding region of lymphocytic choriomeningitis virus lineage V identified in wood mice, Germany (boldface), and reference sequences. Bayesian inference method was used to analyze the 1,674-nt open reading frame corresponding to codons 1–558 without the stop codon. GenBank accession number, strain name, host species, and country of origin (if known) are shown. Roman numerals I–IV represent the different virus lineages as defined previously (10). Lunk virus from Mus minutoides mice was used as an outgroup. WE and Armstrong are laboratory strains of lymphocytic choriomeningitis virus. Scale bar indicates nucleotide substitutions per site. Asyl, Apodemus sylvaticus; AU, Australia; BG, Bulgaria; CN, China; CZ, Czech Republic; DE, Germany; ES, Spain; FR, France; GA, Gabon; GF, French Guiana; JP, Japan; Mm, Mus musculus; Mmm, M. musculus musculus; Mmd, M. musculus domesticus; SK, Slovakia; US, United States; YU, former Yugoslavia.

Main Article

References
  1. Meyer  BJ, de la Torre  JC, Southern  PJ. Arenaviruses: genomic RNAs, transcription, and replication. Curr Top Microbiol Immunol. 2002;262:139–57. DOIPubMedGoogle Scholar
  2. Ackermann  R, Stille  W, Blumenthal  W, Helm  EB, Keller  K, Baldus  O. [Syrian hamsters as vectors of lymphocytic choriomeningitis] [in German]. Dtsch Med Wochenschr. 1972;97:1725–31. DOIPubMedGoogle Scholar
  3. Goldwater  PN. A mouse zoonotic virus (LCMV): A possible candidate in the causation of SIDS. Med Hypotheses. 2021;158:110735. DOIPubMedGoogle Scholar
  4. Asper  M, Hofmann  P, Osmann  C, Funk  J, Metzger  C, Bruns  M, et al. First outbreak of callitrichid hepatitis in Germany: genetic characterization of the causative lymphocytic choriomeningitis virus strains. Virology. 2001;284:203–13. DOIPubMedGoogle Scholar
  5. Ledesma  J, Fedele  CG, Carro  F, Lledó  L, Sánchez-Seco  MP, Tenorio  A, et al. Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain. Emerg Infect Dis. 2009;15:1677–80. DOIPubMedGoogle Scholar
  6. Schmidt  S, Essbauer  SS, Mayer-Scholl  A, Poppert  S, Schmidt-Chanasit  J, Klempa  B, et al. Multiple infections of rodents with zoonotic pathogens in Austria. Vector Borne Zoonotic Dis. 2014;14:467–75. DOIPubMedGoogle Scholar
  7. Kallio-Kokko  H, Laakkonen  J, Rizzoli  A, Tagliapietra  V, Cattadori  I, Perkins  SE, et al. Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy. Epidemiol Infect. 2006;134:830–6. DOIPubMedGoogle Scholar
  8. Mehl  C, Wylezich  C, Geiger  C, Schauerte  N, Mätz-Rensing  K, Nesseler  A, et al. Reemergence of lymphocytic choriomeningitis mammarenavirus, Germany. Emerg Infect Dis. 2023;29:631–4. DOIPubMedGoogle Scholar
  9. Vieth  S, Drosten  C, Lenz  O, Vincent  M, Omilabu  S, Hass  M, et al. RT-PCR assay for detection of Lassa virus and related Old World arenaviruses targeting the L gene. Trans R Soc Trop Med Hyg. 2007;101:1253–64. DOIPubMedGoogle Scholar
  10. Albariño  CG, Palacios  G, Khristova  ML, Erickson  BR, Carroll  SA, Comer  JA, et al. High diversity and ancient common ancestry of lymphocytic choriomeningitis virus. Emerg Infect Dis. 2010;16:1093–100. DOIPubMedGoogle Scholar

Main Article

1Current affiliation: Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany and Justus-Liebig-Universität Gießen, Gießen, Germany.

Page created: November 22, 2023
Page updated: January 24, 2024
Page reviewed: January 24, 2024
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external