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Volume 30, Number 2—February 2024
Dispatch

Inferring Incidence of Unreported SARS-CoV-2 Infections Using Seroprevalence of Open Reading Frame 8 Antigen, Hong Kong

Shi Zhao1, Chris Ka Pun Mok1, Yun Sang Tang, Chunke Chen, Yuanxin Sun, Ka Chun ChongComments to Author , and David S.C. Hui
Author affiliation: Author affiliations: School of Public Health, Tianjin Medical University, Tianjin, China (S. Zhao); JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China (S. Zhao, C.K.P. Mok, Y.S. Tang, C. Chen, Y. Sun, K.C. Chong); Centre for Health Systems and Policy Research, Chinese University of Hong Kong, Hong Kong, China (S. Zhao, K.C. Chong); CUHK Shenzhen Research Institute, Shenzhen, China (S. Zhao, K.C. Chong); Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China (C.K.P. Mok, Y.S. Tang, C. Chen, Y. Sun); S.H. Ho Research Centre for Infectious Diseases, Chinese University of Hong Kong, Hong Kong, China (C.K.P. Mok, D.S.C. Hui)

Main Article

Table

Summary of testing status of SARS-CoV-2 ORF8 ELISA among 1,028 self-claimed uninfected persons, China, 2022*

Stratification ORF8 test, no. ( %)
 Positivity rate, % p value†
Positive Negative
Overall
 26 (100)
 1,002 (100)
 2.5
 NA
Sex
F 12 (46.2) 645 (64.4) 1.8 0.062
M
 14 (53.8)
 357 (35.6)
 3.8
Age, y
<40 6 (23.1) 305 (30.4) 1.9 0.715
40–65 16 (61.5) 566 (56.5) 2.7
>65
 4 (15.4)
 131 (13.1)
 3.0
Test month
March 2 (7.7) 97 (9.7) 2.0 0.608
April 2 (7.7) 137 (13.7) 1.4
May 4 (15.4) 92 (9.2) 4.2
June 18 (69.2) 676 (67.5) 2.6

*NA, not applicable; ORF, open reading frame. †By 2-sided Fisher exact test.

Main Article

1These authors contributed equally to the article.

Page created: November 30, 2023
Page updated: January 24, 2024
Page reviewed: January 24, 2024
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