Volume 30, Number 6—June 2024
Dispatch
Invasive Pulmonary Aspergillosis in Critically Ill Patients with Hantavirus Infection, Austria
Stefan Hatzl, Laura Scholz, Florian Posch, Philipp Eller, Alexander C. Reisinger, Martin Zacharias, Gregor Gorkiewicz, Martin Hoenigl, Ines Zollner-Schwetz, and Robert Krause
Table 2
Characteristics of 2 patients with hantavirus pulmonary aspergillosis and mycological criteria, Graz, Austria*
| Characteristic | Patient 1, DOBV infection | Patient 2, PUUV infection |
|---|---|---|
| EORTC risk factors | None | None |
| APACHE II score | 36 | 26 |
| Thoracic CT scan/radiograph | Bilateral dense infiltrates | Bilateral dense infiltrates |
| Steroids to treat pneumonia | Yes | Yes |
| Renal replacement therapy | Yes | Yes |
| Vasopressor | High-dose nordarenalin and vasopressin | High-dose nordarenalin and vasopressin |
| BAL Aspergillus culture | + | + |
| BAL Aspergillus qPCR | − | − |
| BAL galactomannan index | 7,11 | 7,71 |
| Serum Aspergillus qPCR | NA | NA |
| β-D-glucan, pg/mL | 126 | 626 |
| Serum galactomannan index | 0.79 | 0.32 |
| Mycologic criteria | 4 | 3 |
| Antifungal therapy | Voriconazole | Posaconazole |
| Outcome | Dead | Alive |
*The table summarizes diagnostic and therapeutic characteristics of invasive pulmonary aspergillosis associated with hantavirus-disease. APACHE score, Acute Physiology and Chronic Health Evaluation score; BAL, bronchoalveolar lavage; CT, computed tomography; EORTC, European Organisation for Research and Treatment of Cancer; NA, not available; qPCR, quantitative PCR; +, positive; −, negative.
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