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Volume 30, Number 7—July 2024
CME ACTIVITY - Perspective

Infectious Diseases and Clinical Xenotransplantation

Jay A. FishmanComments to Author  and Nicolas J. Mueller
Author affiliations: Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA (J.A. Fishman); University Hospital Zurich, University of Zurich, Switzerland (N.J. Mueller)

Main Article

Figure

Advances in genetic engineering have led to the breeding of pigs with advantages in infection, immunology, coagulation, size, and inflammation. Breeding of source animals in biosecure facilities enables screening for potential pathogens. B4GalNT2, glycosyltransferase; CD46, human membrane cofactor protein; CD47, block SIRPα tyrosine phosphorylation; CD55, human decay-accelerating factor; CMAH, cytidine monophosphate-N-acetylneuraminic acid hydroxylase; EPCR, endothelial cell protein C receptor; GGAT1, α-1,3-glycosyltransferase; HO1, heme oxygenase-1; HA20, human A20; PERV, porcine endogenous retrovirus; THBD, human thrombomodulin gene.

Figure. Advances in genetic engineering have led to the breeding of pigs with advantages in infection, immunology, coagulation, size, and inflammation. Breeding of source animals in biosecure facilities enables screening for potential pathogens. B4GalNT2, glycosyltransferase; CD46, human membrane cofactor protein; CD47, block SIRPα tyrosine phosphorylation; CD55, human decay-accelerating factor; CMAH, cytidine monophosphate-N-acetylneuraminic acid hydroxylase; EPCR, endothelial cell protein C receptor; GGAT1, α-1,3-glycosyltransferase; HO1, heme oxygenase-1; HA20, human A20; PERV, porcine endogenous retrovirus; THBD, human thrombomodulin gene.

Main Article

Page created: June 03, 2024
Page updated: June 20, 2024
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