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Volume 30, Number 9—September 2024
Research Letter

Emerging Leishmania donovani Lineages Associated with Cutaneous Leishmaniasis, Himachal Pradesh, India, 2023

Patrick Lypaczewski1, Yogesh Chauhan1, Kayla Paulini1, Lovlesh Thakur, Shailja Chauhan, Ezrah Isaac Roy, Greg Matlashewski2Comments to Author , and Manju Jain2
Author affiliations: McGill University, Montreal, Quebec, Canada (P. Lypaczewski, K. Paulini, E.I. Roy, G. Matlashewski); Central University of Punjab, Bathinda, India (Y. Chauhan, M. Jain); Cleveland State University Center for Gene Regulation in Health and Disease, Cleveland, Ohio, USA (L. Thakur); Indira Gandhi Medical College Cancer Hospital, Shimla, India (S. Chauhan)

Main Article

Figure

Phylogeny of Leishmania donovani lineages associated with cutaneous leishmaniasis, Himachal Pradesh, India, 2023. Novel L. donovani from this study (green) are compared with the global population of the 684 parasites previously reported in the L. donovani complex, including reference strains L. donovani LV9, L. donovani BHU 1220, and L. donovani BPK282A1. The previously isolated interspecific hybrid LdHPCL66 (red) falls halfway between the unique LDBPK512 and Yeti-ISC1 lineages. The novel LdHPCL71 and LdHPCL76 (green) nonhybrid parasites are more closely related to the unique LdBPK512 parasite. Scale bar indicates the modified Euclidian distance as calculated by TASSEL (https://tassel.bitbucket.io).

Figure. Phylogeny of Leishmania donovani lineages associated with cutaneous leishmaniasis, Himachal Pradesh, India, 2023. Novel L. donovani from this study (green) are compared with the global population of the 684 parasites previously reported in the L. donovani complex, including reference strains L. donovani LV9, L. donovani BHU 1220, and L. donovani BPK282A1. The previously isolated interspecific hybrid LdHPCL66 (red) falls halfway between the unique LDBPK512 and Yeti-ISC1 lineages. The novel LdHPCL71 and LdHPCL76 (green) nonhybrid parasites are more closely related to the unique LdBPK512 parasite. Scale bar indicates the modified Euclidian distance as calculated by TASSEL (https://tassel.bitbucket.io).

Main Article

1These first authors contributed equally to this article.

2These authors were co–principal investigators.

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