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Volume 31, Number 10—October 2025

Dispatch

Antimicrobial-Resistant Clonal Complex 11 Neisseria meningitidis–Associated Urethritis Cluster, Thailand

John C. Cartee1, Thitima Cherdtrakulkiat12, Sandeep J. Joseph, Rossaphorn Kittiyaowamarn, Natnaree Girdthep, Pongsathorn Sangprasert, Porntip Paopang, Thidathip Wongsurawat, Piroon Jenjaroenpun, Perapon Nitayanon, Rebekah Frankson, Silvina Masciotra, Teodora Wi, Ismael Maatouk, Ellen N. Kersh, Andrey S. Borisov, and Chanwit TribuddharatComments to Author 
Author affiliation: US Centers for Disease Control and Prevention, Atlanta, Georgia, USA (J.C. Cartee, T. Cherdtrakulkiat, S.J. Joseph, R. Frankson, S. Masciotra, E.N. Kersh, A.S. Borisov); Thailand Ministry of Public Health­–US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand (T. Cherdtrakulkiat, S. Masciotra, A.S. Borisov); Ministry of Public Health, Nonthaburi (R. Kittiyaowamarn, N. Girdthep, P. Sangprasert, P. Paopang); Mahidol University, Bangkok, Thailand (T. Wongsurawat, P. Jenjaroenpun, P. Nitayanon, C. Tribuddharat); World Health Organization, Geneva, Switzerland (T. Wi, I. Maatouk)

Main Article

Table

MICs of 16 isolates from investigation of antimicrobial-resistant clonal complex 11 Neisseria meningitidis–associated urethritis cluster, Thailand*

Isolate no. Azithromycin MIC Cefixime MIC Ceftriaxone†
 Ciprofloxacin‡
 Gentamicin MIC
MIC CLSI category MIC CLSI category
NM1 0.75 <0.016 <0.002 Susceptible 0.002 Susceptible 1.5
NM2 1 <0.016 0.002 Susceptible 0.003 Susceptible 3
NM3 0.75 <0.016 <0.002 Susceptible 0.003 Susceptible 3
NM4 0.5 <0.016 <0.002 Susceptible 0.002 Susceptible 3
NM5 0.75 <0.016 <0.002 Susceptible 0.003 Susceptible 3
NM6 1 0.016 0.003 Susceptible 0.004 Susceptible 2
NM7 0.25 0.75 0.38 NA 0.006 Susceptible 2
NM8 1 <0.016 <0.002 Susceptible 0.125 Resistant 3
NM9 1 <0.016 <0.002 Susceptible 0.006 Susceptible 3
NM10 0.38 <0.016 <0.002 Susceptible 1.5 Resistant 3
NM11 0.38 <0.016 <0.002 Susceptible 0.003 Susceptible 2
NM12 0.75 <0.016 <0.002 Susceptible 0.003 Susceptible 3
NM13 1 <0.016 <0.002 Susceptible <0.002 Susceptible 3
NM14 0.38 <0.016 <0.002 Susceptible 0.004 Susceptible 2
NM15 0.5 <0.016 <0.002 Susceptible 0.003 Susceptible 3
NM16 0.25 <0.016 0.002 Susceptible 0.38 Resistant 1.5

*MIC values are µg/mL. Antimicrobial susceptibility testing was conducted by gradient strips. Categorical designations are shown for antimicrobial drugs with official clinical breakpoints for N. meningitidis based on CLSI guidelines (13). CLSI, Clinical and Laboratory Standards Institute (Wayne, Pennsylvania, USA); NA, not available. †N. meningitidis is considered susceptible to ceftriaxone when the MIC values are <0.12 µg/mL. CLSI does not define a resistant category for ceftriaxone for N. meningitidis because a resistant breakpoint has not yet been established. ‡ N. meningitidis is considered resistant to ciprofloxacin when the MIC values are >0.12 µg/mL.

Main Article

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Main Article

1These first authors contributed equally to this article.

2Current affiliation: Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Page created: August 19, 2025
Page updated: September 25, 2025
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