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Volume 31, Number 2—February 2025
Online Report

Adaptive Design for Phase II/III Platform Trial of Lassa Fever Therapeutics

Josephine BournerComments to Author , Michel Vaillant, Alex Paddy Abdel Salam, Marie Jaspard, Camille Fritzell, Shevin T. Jacob, Tom E. Fletcher, Michael Ramharter, Nnennaya Ajayi, Sylvanus Okogbenin, Cyril Erameh, Donald Grant, Robert Samuels, Oladele Oluwafemi Ayodeji, Armand Sprecher, Bronner P. Gonçalves, Tansy Edwards, Piero Olliaro, and the WALC Work Package 2 Working Group
Author affiliation: University of Oxford, Oxford, UK (J. Bourner, A.P.A. Salam, B.P. Gonçalves, P. Olliaro); Luxembourg Institute of Health, Strassen, Luxembourg (M. Vaillant); Sorbonne Université, Paris, France (M. Jaspard); St Antoine Hospital, Paris (M. Jaspard); The Alliance for International Medical Action, Dakar, Senegal (M. Jaspard); Inserm, Bordeaux, France (C. Fritzell); Liverpool School of Tropical Medicine, Liverpool, UK, S.T. Jacob, T.E. Fletcher); University Medical Center Hamburg-Eppendorf, Hamburg, Germany (M. Ramharter); German Center for Infection Research, Riems, Germany (M. Ramharter); Alex Ekwueme Federal University Teaching Hospital, Abakaliki, Nigeria (N. Ajayi); Irrua Specialist Teaching Hospital, Irrua, Nigeria (S. Okogbenin, C. Erameh); Kenema General Hospital, Kenema, Sierra Leone (D. Grant, R. Samuels); Federal Medical Centre, Owo, Nigeria (O.O. Ayodeji); Médecins sans Frontières, Brussels, Belgium (A. Sprecher); London School of Hygiene and Tropical Medicine, London, UK (T. Edwards)

Main Article

Table 1

Ribavirin regimens for treating adult patients with Lassa fever (12)

Regimen, period, days
 Dose
 Frequency/duration
McCormick
1 (loading dose) 33 mg/kg (maximum 2.64 g) Immediately
1–4 16 mg/kg (maximum 1.28 g) Every 6 h
5–10
 8 mg/kg (maximum 0.64 g)
 Every 8 h
Irrua
Day 1 (loading dose) 100 mg/ kg (maximum 7g) Divided in 2 doses: 2/3 immediately; 1/3 8 h later
2–7 25 mg/kg Once a day
8–10 12.5 mg/kg Once a day

Main Article

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Main Article

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Page updated: January 21, 2025
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