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Volume 31, Number 2—February 2025
Research Letter

Venezuelan Equine Encephalitis Virus Infection in Nonhuman Primate, Guatemala, 2023

Wendy K. Jo, Marta Piche-Ovares, Lincoln Carranza, Carlo Fischer, Sebastian Brünink, Laura Paul, Alejandro Morales, Fernando Martinez, and Jan Felix DrexlerComments to Author 
Author affiliation: Charité–Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Institute of Virology, Berlin, Germany (W.K. Jo, M. Piche-Ovares, C. Fischer, S. Brünink, L. Paul, J.F. Drexler); Wildlife Rescue and Conservation Association, Flores, Guatemala (L. Carranza, A. Morales, F. Martinez); German Centre for Infection Research, associated partner site Charité, Berlin (W.K. Jo, J.F. Drexler)

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Figure 2

Time-scaled Bayesian maximum-clade credibility tree of Venezuelan equine encephalitis virus subtype IE identified in Central America. Bayesian phylogeny of the concatenated nonstructural and structural open reading frames with removal of the coding regions for the C-terminus of nonstructural protein 3 and N terminus of the capsid protein. Taxa indicate GenBank accession number, country abbreviation, and year of collection. Branch tips indicate host by color coding, including a sequence (strain no. 63Z1) isolated from blood of a sick human infected in the rainforest near Sontecamapan, Veracruz, Mexico, in August 1963 (2). Numbers at nodes indicate posterior probabilities of all major branches. Asterisks indicate clades previously used for dating according to a previous publication (3). Bars in node branches represent the 95% height posterior density intervals of the node ages. Scale bar represents time in years. BLZ, Belize; CRI, Costa Rica; GTM, Guatemala; HND, Honduras; MEX, Mexico; NIC, Nicaragua; PAN, Panama; SLV, El Salvador.

Figure 2. Time-scaled Bayesian maximum-clade credibility tree of Venezuelan equine encephalitis virus subtype IE identified in Central America. Bayesian phylogeny of the concatenated nonstructural and structural open reading frames with removal of the coding regions for the C-terminus of nonstructural protein 3 and N terminus of the capsid protein. Taxa indicate GenBank accession number, country abbreviation, and year of collection. Branch tips indicate host by color coding, including a sequence (strain no. 63Z1) isolated from blood of a sick human infected in the rainforest near Sontecamapan, Veracruz, Mexico, in August 1963 (2). Numbers at nodes indicate posterior probabilities of all major branches. Asterisks indicate clades previously used for dating according to a previous publication (3). Bars in node branches represent the 95% height posterior density intervals of the node ages. Scale bar represents time in years. BLZ, Belize; CRI, Costa Rica; GTM, Guatemala; HND, Honduras; MEX, Mexico; NIC, Nicaragua; PAN, Panama; SLV, El Salvador.

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References
  1. Brault  AC, Powers  AM, Holmes  EC, Woelk  CH, Weaver  SC. Positively charged amino acid substitutions in the e2 envelope glycoprotein are associated with the emergence of venezuelan equine encephalitis virus. J Virol. 2002;76:171830. DOIPubMedGoogle Scholar
  2. Scherer  WF, Campillo-Sainz  C, de Mucha-Macías  J, Dickerman  RW, Chia  CW, Zarate  ML. Ecologic studies of Venezuelan encephalitis virus in southeastern Mexico. VII. Infection of man. Am J Trop Med Hyg. 1972;21:7985. DOIPubMedGoogle Scholar
  3. Forrester  NL, Wertheim  JO, Dugan  VG, Auguste  AJ, Lin  D, Adams  AP, et al. Evolution and spread of Venezuelan equine encephalitis complex alphavirus in the Americas. PLoS Negl Trop Dis. 2017;11:e0005693. DOIPubMedGoogle Scholar
  4. Adams  AP, Navarro-Lopez  R, Ramirez-Aguilar  FJ, Lopez-Gonzalez  I, Leal  G, Flores-Mayorga  JM, et al. Venezuelan equine encephalitis virus activity in the Gulf Coast region of Mexico, 2003-2010. PLoS Negl Trop Dis. 2012;6:e1875. DOIPubMedGoogle Scholar
  5. Aguilar  PV, Estrada-Franco  JG, Navarro-Lopez  R, Ferro  C, Haddow  AD, Weaver  SC. Endemic Venezuelan equine encephalitis in the Americas: hidden under the dengue umbrella. Future Virol. 2011;6:72140. DOIPubMedGoogle Scholar
  6. Oberste  MS, Fraire  M, Navarro  R, Zepeda  C, Zarate  ML, Ludwig  GV, et al. Association of Venezuelan equine encephalitis virus subtype IE with two equine epizootics in Mexico. Am J Trop Med Hyg. 1998;59:1007. DOIPubMedGoogle Scholar
  7. Han  BA, Kramer  AM, Drake  JM. Global patterns of zoonotic disease in mammals. Trends Parasitol. 2016;32:56577. DOIPubMedGoogle Scholar
  8. Althouse  BM, Guerbois  M, Cummings  DAT, Diop  OM, Faye  O, Faye  A, et al. Role of monkeys in the sylvatic cycle of chikungunya virus in Senegal. Nat Commun. 2018;9:1046. DOIPubMedGoogle Scholar
  9. Moreira-Soto  A, Torres  MC, Lima de Mendonça  MC, Mares-Guia  MA, Dos Santos Rodrigues  CD, Fabri  AA, et al. Evidence for multiple sylvatic transmission cycles during the 2016-2017 yellow fever virus outbreak, Brazil. Clin Microbiol Infect. 2018;24:1019.e14. DOIPubMedGoogle Scholar
  10. Deardorff  ER, Forrester  NL, Travassos-da-Rosa  AP, Estrada-Franco  JG, Navarro-Lopez  R, Tesh  RB, et al. Experimental infection of potential reservoir hosts with Venezuelan equine encephalitis virus, Mexico. Emerg Infect Dis. 2009;15:51925. DOIPubMedGoogle Scholar

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