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Volume 31, Number 3—March 2025
Dispatch

Cefotaxime-Resistant Neisseria meningitidis Sequence Type 4821 Causing Fulminant Meningitis

Youxing Shao1, Mingliang Chen1, Jiehao Cai, Yohei Doi, Min Chen, Minggui Wang, Mei ZengComments to Author , and Qinglan GuoComments to Author 
Author affiliation: Author affiliations: Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China (Y. Shao, M. Wang, Q. Guo); Key Laboratory of Clinical Pharmacology of Antibiotics, National Heath Commission of the People’s Republic of China, Shanghai (Y. Shao, M. Wang, Q. Guo); Minhang Hospital, Fudan University, Shanghai (M. Chen); Children’s Hospital of Fudan University, Shanghai (J. Cai, M. Zeng); University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA (Y. Doi); Fujita Health University School of Medicine, Toyoake, Japan (Y. Doi); Shanghai Municipal Center for Disease Control and Prevention, Shanghai (M. Chen)

Main Article

Figure 1

Epidemiologic and molecular characterizations of penA795-bearing Neisseria meningitidis, N. gonorrhoeae, and Neisseria commensals in study of cefotaxime-resistant N. meningitidis sequence type 4821 causing fulminant meningitis. Epidemiology, molecular typing, antimicrobial resistance determinants, and antimicrobial susceptibility testing results of 85 penA795-bearing Neisseria isolates are shown. The leftmost tree depicts the phylogeny of the PBP2-TPase region (penA 718 to 1,746 bp). Analysis of mutations in antimicrobial resistance-associated genes/determinants is provided in the Appendix. Scale bar indicates number of nucleotide substitutions per site. AMR, antimicrobial resistance; AST, antimicrobial susceptibility testing; CC, clonal complex; CIP, ciprofloxacin; CRO, ceftriaxone; CTX, cefotaxime; MEM, meropenem; MLST, multilocus sequence type; I, intermediate; ND, not determined; PEN, penicillin; R, resistant; sgl, singleton; S, susceptible; UN, unknown.

Figure 1. Epidemiologic and molecular characterizations of penA795-bearing Neisseria meningitidis, N. gonorrhoeae, and Neisseria commensals in study of cefotaxime-resistant N. meningitidis sequence type 4821 causing fulminant meningitis. Epidemiology, molecular typing, antimicrobial resistance determinants, and antimicrobial susceptibility testing results of 85 penA795-bearing Neisseria isolates are shown. The leftmost tree depicts the phylogeny of the PBP2-TPase region (penA 718 to 1,746 bp). Analysis of mutations in antimicrobial resistance-associated genes/determinants is provided in the Appendix. Scale bar indicates number of nucleotide substitutions per site. AMR, antimicrobial resistance; AST, antimicrobial susceptibility testing; CC, clonal complex; CIP, ciprofloxacin; CRO, ceftriaxone; CTX, cefotaxime; MEM, meropenem; MLST, multilocus sequence type; I, intermediate; ND, not determined; PEN, penicillin; R, resistant; sgl, singleton; S, susceptible; UN, unknown.

Main Article

1These authors contributed equally to this article.

Page created: January 17, 2025
Page updated: February 28, 2025
Page reviewed: February 28, 2025
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