Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link

Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released.

Volume 31, Number 3—March 2025
Dispatch

Cefotaxime-Resistant Neisseria meningitidis Sequence Type 4821 Causing Fulminant Meningitis

Youxing Shao1, Mingliang Chen1, Jiehao Cai, Yohei Doi, Min Chen, Minggui Wang, Mei ZengComments to Author , and Qinglan GuoComments to Author 
Author affiliation: Author affiliations: Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China (Y. Shao, M. Wang, Q. Guo); Key Laboratory of Clinical Pharmacology of Antibiotics, National Heath Commission of the People’s Republic of China, Shanghai (Y. Shao, M. Wang, Q. Guo); Minhang Hospital, Fudan University, Shanghai (M. Chen); Children’s Hospital of Fudan University, Shanghai (J. Cai, M. Zeng); University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA (Y. Doi); Fujita Health University School of Medicine, Toyoake, Japan (Y. Doi); Shanghai Municipal Center for Disease Control and Prevention, Shanghai (M. Chen)

Main Article

Figure 1

Epidemiologic and molecular characterizations of penA795-bearing Neisseria meningitidis, N. gonorrhoeae, and Neisseria commensals in study of cefotaxime-resistant N. meningitidis sequence type 4821 causing fulminant meningitis. Epidemiology, molecular typing, antimicrobial resistance determinants, and antimicrobial susceptibility testing results of 85 penA795-bearing Neisseria isolates. The leftmost tree depicts the phylogeny of the PBP2-TPase region (penA 718 to 1,746 bp). Analysis of mutations in antimicrobial resistance-associated genes/determinants is provided in the Appendix. Scale bar indicates number of nucleotide substitutions per site. AMR, antimicrobial resistance; AST, antimicrobial susceptibility testing; CC, clonal complex; CIP, ciprofloxacin; CRO, ceftriaxone; CTX, cefotaxime; MEM, meropenem; MLST, multilocus sequence type; I, intermediate; ND, not determined; PEN, penicillin; R, resistant; sgl, singleton; S, susceptible; UN, unknown.

Figure 1. Epidemiologic and molecular characterizations of penA795-bearing Neisseria meningitidis, N. gonorrhoeae, and Neisseria commensals in study of cefotaxime-resistant N. meningitidis sequence type 4821 causing fulminant meningitis. Epidemiology, molecular typing, antimicrobial resistance determinants, and antimicrobial susceptibility testing results of 85 penA795-bearing Neisseria isolates. The leftmost tree depicts the phylogeny of the PBP2-TPase region (penA 718 to 1,746 bp). Analysis of mutations in antimicrobial resistance-associated genes/determinants is provided in the Appendix. Scale bar indicates number of nucleotide substitutions per site. AMR, antimicrobial resistance; AST, antimicrobial susceptibility testing; CC, clonal complex; CIP, ciprofloxacin; CRO, ceftriaxone; CTX, cefotaxime; MEM, meropenem; MLST, multilocus sequence type; I, intermediate; ND, not determined; PEN, penicillin; R, resistant; sgl, singleton; S, susceptible; UN, unknown.

Main Article

1These authors contributed equally to this article.

Page created: January 17, 2025
Page updated: February 21, 2025
Page reviewed: February 21, 2025
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external