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Volume 31, Number 6—June 2025

CME ACTIVITY - Synopsis

Multicenter Retrospective Study of Spiroplasma ixodetis Infantile Cataract in 8 Countries in Europe

Luc Van OsComments to Author , Nathalie Cassoux, Symira Cholidis, Pascal Dureau, Navid Farassat, Fabienne Catherine Fierz, Ebba Ghyczy, Elena-Cristina Nitulescu, Eva Stifter, Marie-José Tassignon, Anne Le Flèche-Matéos1, Birgit Lorenz1, and for the Spiroplasma Infantile Cataract Group2
Author affiliation: University Hospital Antwerp, Edegem, Belgium (L. Van Os, M. Tassignon); University of Antwerp, Antwerp, Belgium (L. Van Os, M.-J. Tassignon); Institut Curie, Paris, France (N. Cassoux); Université Paris Descartes, Paris (N. Cassoux); Oslo University Hospital, Oslo, Norway (S. Cholidis); Rothschild Foundation Hospital, Paris (P. Dureau); Medical Center–University of Freiburg, Freiburg, Germany (N. Farassat); University Hospital Zurich, Zurich, Switzerland (F.C. Fierz); Cantonal Hospital Winterthur, Winterthur, Switzerland (F.C. Fierz); Amsterdam University Medical Centers, Amsterdam, the Netherlands (E. Ghyczy); Emergency Children’s Hospital Marie Sklodowska Curie, Bucharest, Romania (E.-C. Nitulescu); Medical University of Vienna, Vienna, Austria (E. Stifter); Institut Pasteur, Paris (A. Le Fleche-Matéos); Justus Liebig University Giessen, Giessen, Germany (B. Lorenz)

Main Article

Table

Common clinical manifestations documented in multicenter retrospective study of Spiroplasma ixodetis infantile cataract in 8 countries in Europe that should prompt the clinician to consider a diagnosis of S. ixodetis–related infantile cataract with uveitis*

Clinical manifestation in eyes (%) Characteristics (%) Additional comments
Lens opacity (100), can be highly asymmetric
 Bilateral (55.6) NA
Unilateral (44.4) NA
Progressive over time (46.4) NA
White lens opacity (35.7) NA
Abnormal lens anatomy (25)
 Fibrous plaque, fibrovascular membranes, improperly formed lens
Anterior uveitis (96.4), can be highly asymmetric
 Extensive posterior synechiae (96.4) May lead to the full seclusion of the pupil and increased intraocular pressure with enlarged corneal diameter
Large endothelial precipitates (89.3) Peculiar shape over the entire surface of the cornea
Dilated immature iris vessels (71.4) Can be adherent to the anterior lens capsule or to a pupillary membrane
Pupillary membranes (50) NA
Involvement of the posterior segment (14.3)
 Inflammation, retinal scars
Elevated intraocular pressure* (42.8) Preoperative (14.3) NA
Postoperative (25) NA
Pre and postoperative (3.6) NA
Requiring glaucoma surgery (14.3) NA

*We defined elevated intraocular pressure as the need for treatment for increased eye pressure on the basis of the treating physicians clinical judgement. NA, not applicable.

Main Article

1These senior authors contributed equally to this article.

2Additional members of the Spiroplasma Infantile Cataract Group who contributed data are listed at the end of this article.

Page created: April 23, 2025
Page updated: May 28, 2025
Page reviewed: May 28, 2025
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