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Volume 31, Number 6—June 2025

Dispatch

Cadaveric Human Growth Hormone–Associated Creutzfeldt-Jakob Disease with Long Latency Period, United States

Anatevka S. RibeiroComments to Author , Andrew B. Wolf, Ellen W. Leschek, Lawrence B. Schonberger, Joseph Y. Abrams, Ryan A. Maddox, Brian S. Appleby, Katie Glisic, Aaron Carlson, and Elizabeth Matthews
Author affiliation: University of California, Irvine, Orange, California, USA (A.S. Ribeiro); University of Colorado School of Medicine, Aurora, Colorado, USA (A.S. Ribeiro, A.B. Wolf); National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases, Bethesda, Maryland, USA (E.W. Leschek); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (L.B. Schonberger, J.Y. Abrams, R.A. Maddox); Case Western Reserve University, National Prion Disease Pathology Surveillance Center, Cleveland, Ohio, USA (B.S Appleby, K. Glisic); University Hospitals Cleveland Medical Center, Cleveland (B.S. Appleby, K. Glisic); University of Colorado Anschutz Medical Campus, Aurora (A. Carlson, E. Matthews)

Main Article

Figure 1

Magnetic resonance imaging of the brain from a case of cadaveric human growth hormone–associated Creutzfeldt-Jakob disease with long latency period, United States. A, B) Images obtained at initial clinical examination were unremarkable. C, D) Images obtained 3 months later demonstrated subtle areas of symmetric T2 hyperintensity in the insulae and frontotemporal lobes (C) and deep gray structures with diffusion restriction along the bilateral insulae and caudate heads without gadolinium enhancement (D).

Figure 1. Magnetic resonance imaging of the brain from a case of cadaveric human growth hormone–associated Creutzfeldt-Jakob disease with long latency period, United States. A, B) Images obtained at initial clinical examination were unremarkable. C, D) Images obtained 3 months later demonstrated subtle areas of symmetric T2 hyperintensity in the insulae and frontotemporal lobes (C) and deep gray structures with diffusion restriction along the bilateral insulae and caudate heads without gadolinium enhancement (D).

Main Article

Page created: April 16, 2025
Page updated: May 14, 2025
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