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Volume 31, Number 6—June 2025

Dispatch

Skin Infections Caused by Panton-Valentine Leukocidin and Methicillin-Susceptible Staphylococcus aureus in Child, Japan

Kensuke ShojiComments to Author , Kazue Yoshida, Marie Takenouchi, Junzo Hisatsune, Shoko Kutsuno, Chika Arai, Kanako Masuda, Motoyuki Sugai, Takashi Ishikawa, Toshinao Kawai, Kazuhiro Uda, and Isao Miyairi
Author affiliation: National Center for Child Health and Development, Tokyo, Japan (K. Shoji, K. Yoshida, M. Takenouchi, T. Ishikawa, T. Kawai, K. Uda, I. Miyairi); National Institute of Infectious Diseases, Japan Institute for Health Security, Tokyo (J. Hisatsune, S. Kutsuno, C. Arai, M. Sugai); Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan (J. Hisatsune, S. Kutsuno, C. Arai, K. Masuda, M. Sugai); Okayama University Hospital, Okayama, Japan (K. Uda); Hamamatsu University School of Medicine, Hamamatsu, Japan (I. Miyairi)

Main Article

Table

Genetic characteristics of strains isolated in study of skin infections caused by Panton-Valentine leukocidin and methicillin-susceptible Staphylococcus aureus in child, Japan

ID Source ST Relevant molecular characteristics
JH62M Mother ST2233 TGs: pvl, ete, seg, seh, sei, sem, sen, seo, ses, seu
ARGs: blaZ, GrlA/S80Y, GyrA/S84L
DRGs: none
JH62PP1 Patient ST2233 TGs: pvl, ete, seg, seh, sei, sem, sen, seo, ses, seu
ARGs: blaZ, GrlA/S80Y, GyrA/S84L
DRGs: none
JH62PN Patient ST2233 TGs: pvl, ete, seg, seh, sei, sem, sen, seo, ses, seu
ARGs: blaZ, GrlA/S80Y, GyrA/S84L
DRGs: none
JH62B1 Older brother ST2233 TGs: pvl, ete, seg, seh, sei, sem, sen, seo, ses, seu
ARGs: blaZ, GrlA/S80Y, GyrA/S84L
DRGs: none
JH62F Father ST2233 TGs: pvl, ete, seg, she, sei, sem, sen, seo, ses, seu
ARGs: blaZ, GrlA/S80Y, GyrA/S84L
DRGs: none
JH62B2 Younger brother ST188 TGs: none
ARGs: none
DRGs: none
JH62PP2 Patient (second time) ST1 TGs: sea, seh, sek, seq, ses
ARGs: blaZ, ant(9)-Ia, erm(A)
DRGs: none
*ARG, antimicrobial-resistance gene; DRG; disinfectant-resistance gene; ID, identification; ST, sequence type; TG, toxin gene.

Main Article

References
  1. Vella  V, Galgani  I, Polito  L, Arora  AK, Creech  CB, David  MZ, et al. Staphylococcus aureus skin and soft tissue infection recurrence rates in outpatients: a retrospective database study at 3 US medical centers. Clin Infect Dis. 2021;73:e1045–53. DOIPubMedGoogle Scholar
  2. McNeil  JC, Fritz  SA. Prevention strategies for recurrent community-associated Staphylococcus aureus skin and soft tissue infections. Curr Infect Dis Rep. 2019;21:12. DOIPubMedGoogle Scholar
  3. Liu  C, Bayer  A, Cosgrove  SE, Daum  RS, Fridkin  SK, Gorwitz  RJ, et al.; Infectious Diseases Society of America. Clinical practice guidelines by the infectious diseases society of america for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children. Clin Infect Dis. 2011;52:e18–55. DOIPubMedGoogle Scholar
  4. Bourigault  C, Corvec  S, Brulet  V, Robert  PY, Mounoury  O, Goubin  C, et al. Outbreak of skin infections due to Panton-Valentine leukocidin-positive methicillin-susceptible Staphylococcus aureus in a French prison in 2010–2011. PLoS Curr. 2014;6:ecurrents.outbreaks.e4df88f057fc49e2560a235e0f8f9fea
  5. Gopal Rao  G, Batura  R, Nicholl  R, Coogan  F, Patel  B, Bassett  P, et al. Outbreak report of investigation and control of an outbreak of Panton-Valentine Leukocidin-positive methicillin-sensitive Staphylococcus aureus (PVL-MSSA) infection in neonates and mothers. BMC Infect Dis. 2019;19:178. DOIPubMedGoogle Scholar
  6. Inagawa  T, Hisatsune  J, Kutsuno  S, Iwao  Y, Koba  Y, Kashiyama  S, et al. Genomic characterization of Staphylococcus aureus isolated from patients admitted to intensive care units of a tertiary care hospital: epidemiological risk of nasal carriage of virulent clone during admission. Microbiol Spectr. 2024;12:e0295023. DOIPubMedGoogle Scholar
  7. Coll  F, Raven  KE, Knight  GM, Blane  B, Harrison  EM, Leek  D, et al. Definition of a genetic relatedness cutoff to exclude recent transmission of meticillin-resistant Staphylococcus aureus: a genomic epidemiology analysis. Lancet Microbe. 2020;1:e328–35. DOIPubMedGoogle Scholar
  8. Hetem  DJ, Bonten  MJ. Clinical relevance of mupirocin resistance in Staphylococcus aureus. J Hosp Infect. 2013;85:249–56. DOIPubMedGoogle Scholar
  9. Furi  L, Ciusa  ML, Knight  D, Di Lorenzo  V, Tocci  N, Cirasola  D, et al.; BIOHYPO Consortium. Evaluation of reduced susceptibility to quaternary ammonium compounds and bisbiguanides in clinical isolates and laboratory-generated mutants of Staphylococcus aureus. Antimicrob Agents Chemother. 2013;57:3488–97. DOIPubMedGoogle Scholar
  10. Imanishi  I, Nicolas  A, Caetano  AB, Castro  TLP, Tartaglia  NR, Mariutti  R, et al. Exfoliative toxin E, a new Staphylococcus aureus virulence factor with host-specific activity. Sci Rep. 2019;9:16336. DOIPubMedGoogle Scholar
  11. Sabat  AJ, Wouthuyzen-Bakker  M, Rondags  A, Hughes  L, Akkerboom  V, Koutsopetra  O, et al. Case Report: Necrotizing fasciitis caused by Staphylococcus aureus positive for a new sequence variant of exfoliative toxin E. Front Genet. 2022;13:964358. DOIPubMedGoogle Scholar
  12. Rodriguez  M, Hogan  PG, Burnham  CA, Fritz  SA. Molecular epidemiology of Staphylococcus aureus in households of children with community-associated S aureus skin and soft tissue infections. J Pediatr. 2014;164:105–11. DOIPubMedGoogle Scholar
  13. Hogan  PG, Parrish  KL, Mork  RL, Boyle  MG, Muenks  CE, Thompson  RM, et al. HOME2 study: household versus personalized decolonization in households of children with methicillin-resistant Staphylococcus aureus skin and soft tissue infection—a randomized clinical trial. Clin Infect Dis. 2021;73:e4568–77. DOIPubMedGoogle Scholar

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