Volume 31, Number 7—July 2025
Research Letter
Septic Arthritis and Osteomyelitis in Finger Caused by Mycoplasma phocimorsus from Brown Bear, Alaska, USA
Abstract
Mycoplasma phocimorsus is an identified zoonotic agent of musculoskeletal infections. Osteomyelitis developed in a patient after injury sustained while skinning a bear, and he experienced delayed diagnosis after ineffective treatments. Clinicians should use doxycycline or moxifloxacin therapy in treatment-refractory cases with exposure to seals, cats, or bears while awaiting molecular diagnostics results.
In September 2024, a 29-year-old hunter sought care 7 days after he lacerated his left fifth finger while skinning a brown bear (Ursus arctos) on the Alaska Peninsula near Ivanof Bay, Alaska, USA. The injury occurred when separating paw bones to free skin. His hand and knife contacted the bear’s mouth before injury, but the intestinal tract was not penetrated. He reported 3 days of redness and painful swelling over the proximal interphalangeal (PIP) joint. He was placed on oral trimethoprim/sulfamethoxazole (160 mg/800 mg) and topical mupirocin (2% cream, 3×/d). On day 5 of illness, he developed fever and tachycardia and was admitted to a hospital. His temperature was 38.2°C and pulse 108 beats/min; blood pressure and respiratory rate were unremarkable. A laceration with scant drainage but substantial edema was present over the dorsal left fifth PIP joint (Figure 1). Peripheral leukocyte count was 8,300 cells/μL (reference range 4,500–11,0000 cells/μL), and C-reactive protein level was 11.6 mg/L (reference range 0.2–3.0 mg/L). Radiographs showed soft tissue swelling without bone or joint abnormality.
We administered 1 dose of ceftriaxone (2 g), followed by piperacillin/tazobactam (3 g/375 mg every 8 h) and vancomycin (1.25 g every 8 h) for 3 days. We performed surgery on day 6 of illness and noted left fifth finger PIP septic arthritis and necrotic extensor tendon disruption. Gram stains of debrided tissue revealed no organisms. We inoculated tissue on tryptic soy agar with 5% sheep blood, chocolate blood agar, and MacConkey agar plates and in chopped meat broth and prepared Brucella blood agar, phenylethyl alcohol blood, and Bacteroides bile esculin and laked Brucella blood agar with kanamycin and vancomycin plates. We saw no growth after 7-day incubation. Blood monitored for 5 days on a BACTEC-FX blood culture system (Becton Dickinson, https://www.bd.com) grew no organisms. Fever resolved on day 6 of illness, and on day 8 of illness, we discharged the patient with trimethoprim/sulfamethoxazole (160 mg/800 mg 2×/d for 21 d) and amoxicillin/clavulanate (875 mg/125 mg 2×/d for 21 d).
On day 46 of illness, the patient had repeat debridement of the finger because of persistent swelling and magnetic resonance imaging evidence of PIP joint osteomyelitis (Figure 2). Leukocyte count was 10,300 cells/μL, erythrocyte sedimentation rate was 5 mm/h (reference range <15 mm/h), and C-reactive protein level was 8.6 mg/L. Vancomycin and piperacillin/tazobactam treatment was repeated concurrently for 3 days. At surgery, we found substantial cartilage and bone erosive changes in the PIP joint. Gram stain of operative tissue revealed no organisms, and we detected no growth in conventional aerobic and anaerobic bacterial cultures after 7-day incubation. Fungal cultures inoculated on Sabouraud and brain-heart infusion agar showed no growth. On day 49 of illness, doxycycline (100 mg 2×/d) was started.
On day 53 of illness, tissue from surgery sent to the University of Washington Molecular Microbiology Laboratory for broad-range 16S rDNA PCR bacterial detection revealed Mycoplasma phocimorsus (GenBank accession no. PV641041) using methods described elsewhere (1). The amplified 315-nt sequence was 100% identical with the 16S rRNA gene sequence of M. phocimorsus type strain M5725.
In December 2024, the patient completed 42 days of doxycycline according to standard treatment guidelines for osteomyelitis. Although pain and swelling improved, decreased range of motion persisted at the end of therapy. One month later, he had no signs or symptoms of relapsing infection.
Seal finger was described in 1907 as a painful swollen finger that developed after an injury when butchering seals (2). In 2014, several authors treated a ringed seal (Pusa hispida) hunter in Alaska for seal finger and hip septic arthritis caused by a Mycoplasma species detected by 16s rRNA sequencing, but they could not propogate the organism in culture (3). Nine years later, researchers isolated 6 independent strains of a Mycoplasma species from patients from Scandinavia after contact with seals and proposed the name M. phocimorsus (4). Strains were susceptible to doxycycline and moxifloxacin and showed >99.5% rRNA similarity with the sequence identified in the seal hunter from Alaska, confirming M. phocimorsus is present in Alaska. Subsequently, M. phocimorsus was identified as the cause of tenosynovitis after a cat scratch (5). Our patient had no exposure to seals and minimal exposure to a dog and cat owned by his mother.
Harbor seals (Phoca vitulina), sea otters (Enhydra lutris), and Steller sea lions (Eumetopias jubatus) are encountered in that region of Alaska (D.D.W. Hauser, University of Alaska, pers. comm., email, 2024 Mar 14). Brown bears are voracious hunters and scavengers, so this case may reflect transient colonization after predation of an infected seal or other animal. However, Mycoplasma species occur in brown bear gut microbiomes (6), suggesting that brown bears may be frequent reservoirs of M. phocimorsus. As in previous cases, this patient experienced delayed diagnosis and ineffective treatments because of Mycoplasma species’ resistance to most antibiotic drugs and inability to be grown in conventional cultures. Clinicians should remain alert to the possibility of M. phocimorsus infection after exposure to seals, cats, or bears and initiate doxycycline or moxifloxacin therapy while awaiting confirmatory molecular testing, particularly in treatment-refractory infections.
Dr. Westley is an infectious diseases clinician in Anchorage, Alaska. His research interests include zoonotic diseases, tuberculosis, and HIV.
Acknowledgment
We thank our patient for his replies to our repeated queries regarding specifics of his hunt and his injuries and for his verbal and written permission to publish this report. We also thank the University of Washington Molecular Microbiology Laboratory for providing testing services and the Mycoplasma phocimorsus sequence.
References
- Lee SA, Plett SK, Luetkemeyer AF, Borgo GM, Ohliger MA, Conrad MB, et al. Bartonella quintana aortitis in a man with AIDS, diagnosed by needle biopsy and 16S rRNA gene amplification. J Clin Microbiol. 2015;53:2773–6. DOIPubMedGoogle Scholar
- Bidenknap JH. Seal finger [in Dutch]. Norsh Mag Legevidenskaben. 1907;68:515–23.
- Westley BP, Horazdovsky RD, Michaels DL, Brown DR. Identification of a novel Mycoplasma species in a patient with septic arthritis of the hip and seal finger. Clin Infect Dis. 2016;62:491–3. DOIPubMedGoogle Scholar
- Skafte-Holm A, Pedersen TR, Frølund M, Stegger M, Qvortrup K, Michaels DL, et al. Mycoplasma phocimorsus sp. nov., isolated from Scandinavian patients with seal finger or septic arthritis after contact with seals. Int J Syst Evol Microbiol. 2023;73:
006163 . DOIPubMedGoogle Scholar - Skafte-Holm A, Pedersen TR, Frølund M, Stegger M, Hallstrøm S, Rasmussen A, et al. Mycoplasma phocimorsus in woman with tendinous panaritium after cat scratch, Denmark. Emerg Infect Dis. 2025;31:380–2.PubMedGoogle Scholar
- Trujillo SM, McKenney EA, Hilderbrand GV, Mangipane LS, Rogers MC, Joly K, et al. Correlating gut microbial membership to brown bear health metrics. Sci Rep. 2022;12:15415. DOIPubMedGoogle Scholar
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Cite This ArticleOriginal Publication Date: June 17, 2025
Table of Contents – Volume 31, Number 7—July 2025
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Please use the form below to submit correspondence to the authors or contact them at the following address:
Benjamin P. Westley, 3500 LaTouche St, Ste 200, Anchorage, AK 99508, USA
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