Volume 32, Number 5—May 2026
Etymologia
Borealpox [bōr′-ē-әl-poks]
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The emerging borealpox virus causes zoonotic borealpox disease, characterized by dermal lesions, in humans. From the Latin adjective borealis, which refers to Boreas (βορέας), the Greek god of the north wind, boreal has indicated northern origin since the 15th Century.
The orthopoxvirus isolate AK2015_poxvirus was isolated from a resident of Fairbanks, Alaska, USA, in 2015, and initially dubbed Alaskapox virus after complete genome sequence analysis revealed a novel species similar to Old World orthopoxviruses. Seven human cases, including 1 fatal case, preceded renaming to borealpox virus. Boreal references the taiga, a subarctic coniferous forest ecosystem where case-patients and likely small mammal virus reservoirs resided.
References
- Gigante CM, Gao J, Tang S, McCollum AM, Wilkins K, Reynolds MG, et al. Genome of Alaskapox virus, a novel orthopoxvirus isolated from Alaska. Viruses. 2019;11:708. DOIPubMedGoogle Scholar
- Mooring EQ, Rogers J, Whitehill F, Werle Z, Gigante CM, Matheny A, et al. Six cases of borealpox and evidence of a zoonotic source—Alaska, 2020–2023. Clin Infect Dis. 2025;•••: Epub ahead of print. DOIPubMedGoogle Scholar
- Rogers JH, Westley B, Mego T, Newell KG, Laurance J, Smith L, et al. Fatal borealpox in an immunosuppressed patient treated with antivirals and vaccinia immunoglobulin—Alaska, 2023. Clin Infect Dis. 2025;80:1053–9. DOIPubMedGoogle Scholar
- Springer YP, Hsu CH, Werle ZR, Olson LE, Cooper MP, Castrodale LJ, et al. Novel orthopoxvirus infection in an Alaska resident. Clin Infect Dis. 2017;64:1737–41. DOIPubMedGoogle Scholar
Original Publication Date: April 27, 2026
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Table of Contents – Volume 32, Number 5—May 2026
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Please use the form below to submit correspondence to the authors or contact them at the following address:
JJ L. Miranda, Department of Biology, Barnard College, 3009 Broadway, New York, NY 10027, USA
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