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Volume 4, Number 2—June 1998


Multidrug-Resistant Mycobacterium tuberculosis: Molecular Perspectives

Ashok RattanComments to Author , Awdhesh KaliaComments to Author , and Nishat Ahmad
Author affiliations: All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India

Main Article


Gene loci involved in conferring drug-resistance in Mycobacterium tuberculosis

Drug Gene Product Reported frequency 
in resistant 
strainsa (%) Reference
Rifampicin rpoB B-subunit of RNA polymerase >95 45-48,68-71
Isoniazid katG Catalase-peroxidase 60-70 39-48
oxyR-ahpC Alky hydro-reductase ~20 36
INH-Ethionamide inhA Enoyl-ACP reductase <10 46-48
Streptomycin rpsL Ribosomal protein S12 60 46-48
rrs 16s rRNA <10 113-117
Fluoroquinolone gyrA DNA gyrase >90 107
Pyrazinamide pncA Amidase 70-100 92-94
Ethambutol embCAB EmbCAB 69 88

aMutation frequencies are as determined by sequencing and polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis.

Main Article