Volume 5, Number 3—June 1999
Synopsis
Adhesins as Targets for Vaccine Development
Table 1
Adhesins of gram-negative bacteria
Adhesin | Strain | Ligand | Reference |
---|---|---|---|
Pili familya | Hultgren (33) | ||
PapG | Escherichia coli | Gala(1-4)Gal in globoseries of glycolipids | |
SfaS | E. coli | a-sialyl-2 3-b-galactose | |
FimH | E. coli | Mannose-oligosaccharides | |
HifE | Haemophilus influenzae | Sialylyganglioside-GM1 | |
PrsG | E. coli | Gala(1-4)Gal in globoseries of glycolipids | |
MrkD | Klebsiella pneumoniae | Type V collagen | |
FHA | Bordetella pertussis | Sulfated sugars on cell-surface glycoconjugates | Brennan (34) |
Pertactin | B. pertussis | Integrins | Brennan (34) |
HMW1/HMW2 | H. influenzae | Human epithelial cells | St. Geme (35) |
Hia | H. influenzae | Human conjunctival cells | Barenkamp (36) |
Leb-binding adhesin | Helicobacter pylori | Fucosylated Leb histo-blood group antigens | Ilver (37) |
aRepresentative examples from the large family of pilus-associated adhesins. FHA, filamentous hemagglutinin; HMW, high molecular weight; Hia, H. influenzae adhesin
References
- Hilleman MR. Paper presented at the International Symposium on Recombinant Vectors in Vaccine Development; 1993 May 23; Albany, New York. [Nucleic Acids Technologies Foundation, sponsored by IABS, FDA, USDA/APHIS, and NIAID/NIH].
- Alexander J, Fikes J, Hoffman S, Franke E, Sacci J, Appella E, The optimization of helper T lymphocyte (HTL) function in vaccine development. Immunol Res. 1998;18:79–92. DOIPubMedGoogle Scholar
- St Geme JW III. Bacterial adhesins: determinants of microbial colonization and pathogenicity. Adv Pediatr. 1997;44:43–72.PubMedGoogle Scholar
- McGhee J, Mestecky J, Dertzbaugh MT, Eldridge JH, Hirasawa M, Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine. 1992;10:75–88. DOIPubMedGoogle Scholar
- Langermann S. New approaches to mucosal immunization. Semin Gastrointest Dis. 1996;7:12–8.PubMedGoogle Scholar
- O'Hagan DT. Recent advances in vaccine adjuvants for systemic and mucosal administration. J Pharm Pharmacol. 1998;50:1–10.PubMedGoogle Scholar
- Mestecky J, Michalek SM, Moldoveanu Z, Russell MW. Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans. Behring Inst Mitt. 1997;98:33–43.PubMedGoogle Scholar
- Beachey EH. Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. J Infect Dis. 1981;143:325–45.PubMedGoogle Scholar
- Beachey EH, Giampapa CS, Abraham SN. Bacterial adherence: adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces. Am Rev Respir Dis. 1988;138:S45–8.PubMedGoogle Scholar
- Ofek I, Sharon N. Adhesins as lectins: specificity and role in infection. Curr Top Microbiol Immunol. 1990;151:91–113.PubMedGoogle Scholar
- Hultgren SJ, Abraham S, Capron M, Falk P, St. Geme JW, Normark S. Pilus and non-pilus bacterial adhesins: assembly and function in cell recognition. Cell. 1993;73:887–901. DOIPubMedGoogle Scholar
- Jenkinson HF, Lamont RJ. Streptococcal adhesion and colonization. Crit Rev Oral Biol Med. 1997;8:175–200. DOIPubMedGoogle Scholar
- Abraham SN, Sun D, Dale JB, Beachey EH. Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriacaea. Nature. 1988;:682–4. DOIPubMedGoogle Scholar
- Sokurenko EV, Courtney HS, Ohman DE, Klemm P, Hasty DL. FimH family of type 1 fimbrial adhesins: functional heterogeneity due to minor sequence variations among fimH genes. J Bacteriol. 1994;176:748–55.PubMedGoogle Scholar
- Langermann S, Palaszynski S, Barnhart M, Auguste G, Pinkner JS, Burlein J, Prevention of mucosal Escherichia coli infection by FimH-based systemic vaccination. Science. 1997;276:607–11. DOIPubMedGoogle Scholar
- Palaszynski S, Pinkner J, Leath S, Barren P, Auguste CG, Burlein J, Systemic immunization with conserved pilus-associated adhesins protects against mucosal infections. Dev Biol Stand. 1998;92:117–22.PubMedGoogle Scholar
- Finlay B, Falkow S. Common themes in microbial pathogenicity. Microbiol Rev. 1989;53:210–30.PubMedGoogle Scholar
- Hoepelman AI, Tuomanen EI. Consequences of microbial attachment: directing host cell functions with adhesins. Infect Immun. 1992;60:1729–33.PubMedGoogle Scholar
- Svanborg C, Hedlund M, Connell H, Agace W, Duane RD, Nilsson A, Bacterial adherence and mucosal cytokine responses. Receptors and transmembrane signaling. Ann N Y Acad Sci. 1996;797:177–90. DOIPubMedGoogle Scholar
- Falkow S. Invasion and intracellular sorting of bacteria: searching for bacterial genes expressed during host/pathogen interactions. J Clin Invest. 1997;100:239–43. DOIPubMedGoogle Scholar
- Mecsas JJ, Strauss EJ. Molecular mechanisms of bacterial virulence: type III secretion and pathogenicity islands. Emerg Infect Dis. 1996;2:270–88. DOIPubMedGoogle Scholar
- Zhang JP, Normark S. Induction and gene expression in Escherichia coli after pilus-mediated adherence. Science. 1996;273:1234–6. DOIPubMedGoogle Scholar
- Donnenberg MS, Kaper JB, Finlay BB. Interactions between enteropathogenic Escherichia coli and host epithelial cells. Trends Microbiol. 1997;5:109–14. DOIPubMedGoogle Scholar
- Kenny B, DeVinney R, Stein M, Reinscheid DJ, Frey EA, Finlay BB. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell. 1997;91:511–20. DOIPubMedGoogle Scholar
- Svanborg-Eden C, Marild S, Korhonen TK. Adhesion inhibition by antibodies. Scand J Infect Dis. 1982;33:72–8.
- O'Hanley P, Lark D, Falkow S, Schoolnik G. Molecular basis of Escherichia coli colonization of the upper urinary tract in Balb/c mice. Gal-Gal pili immunization prevents Escherichia coli pyelonephritis in the Balb/c mouse model of human pyelonephritis. J Clin Invest. 1985;75:347–60. DOIPubMedGoogle Scholar
- Pecha B, Low D, O'Hanley P. Gal-Gal pili vaccines prevent pyelonephritis by piliated Escherichia coli in a murine model. Single component Gal-Gal pili vaccines prevent pyelonephritis by homologous and heterologous piliated E. coli strains. J Clin Invest. 1989;83:2102–8. DOIPubMedGoogle Scholar
- Moon HW, Bunn TO. Vaccines for preventing enterotoxigenic Escherichia coli infections in farm animals. Vaccine. 1993;11:213–20. DOIPubMedGoogle Scholar
- Maurer L, Orndorff P. Identification and characterization of genes determining receptor binding and pilus length of Escherichia coli type 1 pili. J Bacteriol. 1987;169:640–5.PubMedGoogle Scholar
- Hanson MS, Brinton CC Jr. Identification and characterization of the Escherichia coli type 1 pilus adhesin protein. Nature. 1988;322:265–8. DOIGoogle Scholar
- Bock K, Breimer ME, Brignole A, Hansson GC, Karlsson KA, Larson G, Specificity of binding of a strain of uropathogenic Escherichia coli to Gal 1-4Gal-containing glycosphingolipids. J Biol Chem. 1985;260:8545–51.PubMedGoogle Scholar
- Stromberg N, Marklund BI, Lund B, Ilver D, Hamers A, Gaastra W, Host-specificity of uropathogenic Escherichia coli depends on differences in binding specificity to Gal 1-4Gal-containing isoreceptors. EMBO J. 1990;9:2001–10.PubMedGoogle Scholar
- Hultgren SJ, Jones CH. Utility of the immunoglobulin-like fold of chaperones in shaping organelles of attachment in pathogenic bacteria. American Society for Microbiology News 1195;61:457-64.
- Brennan MJ, Shahin RD. Pertussis antigens that abrogate bacterial adherence and elicit immunity. Am J Respir Crit Care Med. 1996;154:S145–9.PubMedGoogle Scholar
- St. Geme JW III. Progress towards a vaccine for nontypable Haemophilus influenzae. The Finnish Medical Society DUODECIM. Ann Med. 1996;28:31–7. DOIPubMedGoogle Scholar
- Barenkamp SJ, St Geme JW III. Identification of a second family of high-molecular-weight adhesion proteins expressed by non-typable Haemophilus influenzae. Mol Microbiol. 1996;19:1215–23. DOIPubMedGoogle Scholar
- Ilver D, Arnqvist A, Ogren J, Frick IM, Kersulyte D, Incecik ET, Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science. 1998;279:373–7. DOIPubMedGoogle Scholar
- Roberts JA. Tropism in bacterial infections: urinary tract infections. J Urol. 1996;156:1552–9. DOIPubMedGoogle Scholar
- Demuth DR, Duan Y, Brooks W, Holmes AR, McNab R, Jenkinson HF. Tandem genes encode cell-surface polypeptides SspA and SspB which mediate adhesion of the oral bacterium Streptococcus gordonii to human and bacterial receptors. Mol Microbiol. 1996;20:403–13. DOIPubMedGoogle Scholar
- McNab R, Jenkinson HF, Loach DM, Tannock GW. Cell-surface-associated polypeptides CshA and CshB of high molecular mass are colonization determinants in the oral bacterium Streptococcus gordonii. Mol Microbiol. 1994;14:743–5. DOIPubMedGoogle Scholar
- Jonsson K, Signas C, Muller HP, Lindberg M. Two different genes encode fibronectin binding proteins in Staphylococcus aureus. The complete nucleotide sequence and characterization of the second gene. Eur J Biochem. 1991;202:1041–8. DOIPubMedGoogle Scholar
- Talay SR, Valentin-Weigand P, Timmis KN, Chhatwal GS. Domain structure and conserved epitopes of Sfb protein, the fibronectin-binding protein adhesin of Streptococcus pyogenes. Mol Microbiol. 1994;13:531–9. DOIPubMedGoogle Scholar
- Hanski E, Caparon M. Protein F, a fibronectin-binding protein, is an adhesin of the group A streptococcus Streptococcus pyogenes. Proc Natl Acad Sci U S A. 1992;89:6172–6. DOIPubMedGoogle Scholar
- Burnette-Curley D, Wells V, Viscount H, Munro CL, Fenno JC, Fives-Taylor P, FimA, a major virulence factor associated with Streptococcus parasanguis endocarditis. Infect Immun. 1995;63:4669–74.PubMedGoogle Scholar
- Rosenow C, Ryan P, Weiser JN, Johnson S, Fontan P, Ortqvist A, Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol Microbiol. 1997;25:819–29. DOIPubMedGoogle Scholar
- Hammerschmidt S, Talay SR, Brandtzaeg P, Chhatwal GS. SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component. Mol Microbiol. 1997;25:1113–24. DOIPubMedGoogle Scholar
- Briles DE, Hollingshead SK, Swiatlo E, Brooks-Walter A, Szalai A, Virolainen A, PspA and PspC: their potential for use as pneumococcal vaccines. Microb Drug Resist. 1997;3:401–8. DOIPubMedGoogle Scholar
- Smith BL, Cheng Q, Hostetter MK. Characterization of a pneumococcal surface protein that binds complement protein C3 and its role in adhesion [poster D-122]. The American Society for Microbiology (1998) 98th General Meeting; Atlanta, Georgia.
- Hajishengallis G, Russell MW, Michalek SM. Comparison of an adherence domain and a structural region of Streptococcus mutans antigen I/II in protective immunity against dental caries in rats after intranasal immunization. Infect Immun. 1998;66:1740–3.PubMedGoogle Scholar
- Crowley PJ, Brady LJ, Piacentini DA, Bleiweis AS. Identification of a salivary agglutinin-binding domain within cell surface adhesin P1 of Streptococcus mutans. Infect Immun. 1993;61:1547–52.PubMedGoogle Scholar
- Todryk SM, Kelly CG, Lehner T. Effect of route of immunisation and adjuvant on T and B cell epitope recognition within a streptococcal antigen. Vaccine. 1998;16:174–80. DOIPubMedGoogle Scholar
- McNab R, Holmes AR, Clark JM, Tannock GW, Jenkinson HF. Cell surface polypeptide CshA mediates binding of Streptococcus gordonii to other oral bacteria and to immobilized fibronectin. Infect Immun. 1996;64:4202–10.
- Schennings T, Heimdahl A, Coster K, Flock J-I. Immunization with fibronectin binding protein from Staphylococcus aureus protects against experimental endocarditis in rats. Microb Pathog. 1993;15:227–36. DOIPubMedGoogle Scholar
- Lee JC. The prospects for developing a vaccine against Staphylococcus aureus. Trends Microbiol. 1996;4:162–6. DOIPubMedGoogle Scholar
- Molinari G, Talay SR, Valentin-Weigand P, Rohde M, Chhatwal GS. The fibronectin-binding protein of Streptococcus pyogenes, SfbI, is involved in the internalization of group A streptococci by epithelial cells. Infect Immun. 1997;65:1357–63.PubMedGoogle Scholar
- Correia FF, DiRienzo JM, McKay TL, Rosan B. scbA from Streptococcus crista CC5A: an atypical member of the lraI gene family. Infect Immun. 1996;64:2114–21.PubMedGoogle Scholar
- Dintilhac A, Alloing G, Granadel C, Claverys JP. Competence and virulence of Streptococcus pneumoniae: Adc and PsaA mutants exhibit a requirement for Zn and Mn resulting from inactivation of putative ABC metal permeases. Mol Microbiol. 1997;25:727–39. DOIPubMedGoogle Scholar
- Fenno JC, Shaikh A, Spatafora G, Fives-Taylor P. The fimA locus of Streptococcus parasanguis encodes an ATP-binding membrane transport system. Mol Microbiol. 1995;15:849–63. DOIPubMedGoogle Scholar
- Talkington DF, Brown BG, Tharpe JA, Koenig A, Russell H. Protection of mice against fatal pneumococcal challenge by immunization with pneumococcal surface adhesin A (PsaA). Microb Pathog. 1996;21:17–22. DOIPubMedGoogle Scholar
- Berry AM, Paton JC. Sequence heterogenity of PsaA, a 37-kilodalton putative adhesin essential for virulence of Streptococcus pneumoniae. Infect Immun. 1996;64:5255–62.PubMedGoogle Scholar
- Novak R, Brown JS, Charpentier E, Tuamonen E. Penicillin tolerance genes of Streptococcus pneumoniae: the ABC-type manganese permease complex Psa. Mol Microbiol. 1998;29:1285–96. DOIPubMedGoogle Scholar
- Dormizter M, Wizemann TM, Adamou JE, Walsh W, Gayle T, Langermann S, Sequence and structural analysis of CbpA, a novel choline-binding protein of Streptococcus pneumoniae [poster B-3]. The American Society for Microbiology (1998) 98th General Meeting; Atlanta, Georgia.
- Schaeffer AJ, Amundsen SK, Schnidt LN. Adherence of Escherichia coli to human urinary tract epithelial cells. Infect Immun. 1979;24:753–9.PubMedGoogle Scholar
- Ofek I, Mosek A, Sharon N. Mannose-specific adherence of Escherichia coli freshly excreted in the urine of patients with urinary tract infections, and of isolates subcultured from the infected urine. Infect Immun. 1981;34:708–11.PubMedGoogle Scholar
- Connell H, Agace W, Klemm P, Schembri M, Marild S, Svanborg C. Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract. Proc Natl Acad Sci U S A. 1996;93:9827–32. DOIPubMedGoogle Scholar
- Frey A, Neutra MR. Targeting of mucosal vaccines to Peyer's patch M cells. Behring Inst Mitt. 1997;98:376–89.PubMedGoogle Scholar
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