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Volume 5, Number 3—June 1999


Adhesins as Targets for Vaccine Development

Theresa M. Wizemann, John E. Adamou, and Solomon LangermannComments to Author 
Author affiliations: MedImmune, Inc., Gaithersburg, Maryland, USA

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Table 1

Adhesins of gram-negative bacteria

Adhesin Strain Ligand Reference
Pili familya Hultgren (33)
PapG Escherichia coli Gala(1-4)Gal in globoseries of glycolipids
SfaS E. coli a-sialyl-2 3-b-galactose
FimH E. coli Mannose-oligosaccharides
HifE Haemophilus influenzae Sialylyganglioside-GM1
PrsG E. coli Gala(1-4)Gal in globoseries of glycolipids
MrkD Klebsiella pneumoniae Type V collagen
FHA Bordetella pertussis Sulfated sugars on cell-surface glycoconjugates Brennan (34)
Pertactin B. pertussis Integrins Brennan (34)
HMW1/HMW2 H. influenzae Human epithelial cells St. Geme (35)
Hia H. influenzae Human conjunctival cells Barenkamp (36)
Leb-binding adhesin Helicobacter pylori Fucosylated Leb histo-blood group antigens Ilver (37)

aRepresentative examples from the large family of pilus-associated adhesins. FHA, filamentous hemagglutinin; HMW, high molecular weight; Hia, H. influenzae adhesin

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