Volume 7, Number 2—April 2001
THEME ISSUE
4th Decennial International Conference on Nosocomial and Healthcare-Associated Infections
Introduction
The Changing Epidemiology of Staphylococcus aureus?
Henry F. Chambers
Table 4
Elements found within three types of mec-associated DNA
| mec types | |||
|---|---|---|---|
| Genetic featurea | I | II | III |
| Size | 32 kb | 52 kb | 60 kb |
| mecA | + | + | + |
| mecR1-mecI | - | + | + |
| ccrAB | + | + | + |
| pUB110 | - | + | - |
| IS431 (number) | 1 | 2 | 4 |
| Tn554 (number) | 0 | 1 | 2 |
| Tc, Hg resistance | - | - | + |
amecA = gene encoding PBP 2a, the penicillin-binding protein with low binding affinity that mediates methicillin resistance; mecR1-mecI = sensor-transducer and repressor genes that regulate production of inducible PBP 2a; ccrAB = cassette chromosome recombinases A and B that mobilize the mec element; pUB110 = integrated plasmid that encodes tobramycin and kanamycin resistance; IS431 = insertion sequence; Tn554 = erythromycin-resistance encoding transposon; Tc = tetracycline-resistance determinant; Hg = mercury-resistance determinant.
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