Volume 7, Number 2—April 2001
THEME ISSUE
4th Decennial International Conference on Nosocomial and Healthcare-Associated Infections
State of the Art
Emerging Mechanisms of Fluoroquinolone Resistance
David C. Hooper
Table
Components of multidrug transport systems in selected bacterial pathogens
| Efflux components | ||||
|---|---|---|---|---|
| Species |
Pump |
Membrane fusion protein |
Outer membrane protein |
Regulatory gene or mutation |
| Gram-negative bacteria | ||||
| Pseudomonas aeruginosa | MexB | MexA | OprM | mexR |
| MexD | MexC | OprJ | nfxB | |
| MexF | MexE | OprN | mexT | |
| MexY | MexX | OprM | mexZ | |
| Escherichia coli | AcrB | AcrA | TolC | acrR, marA, robA, soxS |
| Gram-positive bacteria | ||||
| Staphylococcus aureus | NorA | -- | -- | flqB promoter mutation, arlRS |
| Streptococcus pneumoniae | PmrA | -- | -- | ? |
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