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Volume 7, Number 4—August 2001
THEME ISSUE
West Nile Virus
West Nile Virus

Rapid Determination of HLA B*07 Ligands from the West Nile Virus NY99 Genome

Anne S. De Groot*†Comments to Author , Caitlin Saint-Aubin*, Andrew Bosma*, Hakima Sbai*, James Rayner†, and William Martin†
Author affiliations: *Brown University, Providence, Rhode Island, USA; †EpiVax, Inc., Providence, Rhode Island, USA

Main Article

Figure 1

Distribution of scores for the complete set of 3,424 peptides obtained by parsing the West Nile (WN) virus genome into 10 amino-acid long peptides, each overlapping by 9 amino acids, as scored on the EpiMatrix motif for HLA B*07. Peptides with estimated binding potential (EBP) scores >7 and <50 with the HLA B*07 motif are highly likely to bind to HLA B*07 in T2 B7 assays and to stimulate T cells. WN virus peptides with EBP scores between 20 and 50 were considered for study.

Figure 1. . . Distribution of scores for the complete set of 3,424 peptides obtained by parsing the West Nile (WN) virus genome into 10 amino-acid long peptides, each overlapping by 9 amino acids, as scored on the EpiMatrix motif for HLA B*07. Peptides with estimated binding potential (EBP) scores >7 and <50 with the HLA B*07 motif are highly likely to bind to HLA B*07 in T2 B7 assays and to stimulate T cells. WN virus peptides with EBP scores between 20 and 50 were considered for study.

Main Article

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