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Volume 7, Number 4—August 2001
THEME ISSUE
West Nile Virus
West Nile Virus

Fatal Encephalitis and Myocarditis in Young Domestic Geese (Anser anser domesticus) Caused by West Nile Virus

David E. Swayne*Comments to Author , Joan R. Beck*, Calandra S. Smith†, Wun-Ju Shieh†, and Sharif R. Zaki†
Author affiliations: *U.S. Department of Agriculture, Agricultural Research Service, Southeast Poultry Research Laboratory, Athens, Georgia, USA; †Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Table

Virus isolation and titration data from 2-week-old domestic geese inoculated with WN virus and samples taken between 0 and 21 days postinoculation (PI)

Plasma virus titers (log10 TCID50/0.1 mL)a by days PI
Group-bird identification 0 1 2 3 4 5 7 10 14 21
Sham controls:
58 - NS - NS - NS - - - -
73 - NS - NS - NS - - - -
WN virus-inoculates:
6 - 1.5 5.5 4.5b 2.5 2.5c Dead Dead Dead Dead
78 - 3.5 4.5 3.5 1.5b 1.5 - - - -
80 - 2.5 5.5 2.5b 1.5 - - -c Dead Dead
86 - 2.5 6.5 5.5 2.5 1.5c Dead Dead Dead Dead
In contacts:
8 - NS - NS - NS - - - -
13 - NS - NS - NS - 2.5 - -

aEndpoints in Vero cell cultures based on CPE and confirmation as WN virus by indirect fluorescent antibody test: NS = No sample, - = No cytopathic effect.
bWN virus isolated from oropharyngeal swabs; #6, 101.5/0.1 mL, #80, 100.5/0.1 mL, #78, 100.5/0.1 mL (reported as tissue culture infective doses [TCID50] titers in oropharyngeal swab media; originally each swab placed in 1.5 mL of phosphate-buffered saline supplemented with 0.75% bovine serum albumin).
cWN virus isolated from tissues at necropsy (TCID50/0.01 g): 1) Gosling #6 (5 days PI) - 103.5 in brain, 104.5 in heart, 101.5 in kidney and 103.5 in intestine; 2) gosling #80 (10 days PI) - 101.5 in brain and 101.5 in intestine; 3) gosling #86 (6 days PI) - 103.5 in brain, 102.5 in heart, 101.5 in kidney and 101.5 in intestine.

Main Article

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Page updated: April 27, 2012
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