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Volume 7, Number 5—October 2001
Research

Clinical Consequences and Cost of Limiting Use of Vancomycin for Perioperative Prophylaxis: Example of Coronary Artery Bypass Surgery

Giorgio Zanetti*†Comments to Author , Sue J. Goldie‡, and Richard Platt*§
Author affiliations: *Channing Laboratory, Brigham and Women's Hospital, and Eastern Massachusetts CDC Prevention Epicenter, Boston, Massachusetts, USA; †University Hospital, Lausanne, Switzerland; ‡Harvard School of Public Health, Boston, Massachusetts, USA; §Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA

Main Article

Figure 2

Three-way sensitivity analysis of the incidence of surgical site infection (SSI) caused by methicillin-resistant Staphylococcus aureus (MRSA); methicillin-resistant coagulase-negative staphylococci; or cefazolin-susceptible gram-negative bacteria. The lines show the incidence of infection caused by methicillin-resistant Staphylococcus aureus necessary for routine cefazolin prophylaxis to be more cost-effective than routine vancomycin (0.09%, 0.6%, 1.2%, and 1.8%). For a particular line, points t

Figure 2. . Three-way sensitivity analysis of the incidence of surgical site infection (SSI) caused by methicillin-resistant Staphylococcus aureus (MRSA); methicillin-resistant coagulase-negative staphylococci; or cefazolin-susceptible gram-negative bacteria. The lines show the incidence of infection caused by methicillin-resistant Staphylococcus aureus necessary for routine cefazolin prophylaxis to be more cost-effective than routine vancomycin (0.09%, 0.6%, 1.2%, and 1.8%). For a particular line, points to the lower right indicate that routine vancomycin is more cost-effective; points to the upper left indicate that routine cefazolin is more cost-effective. The dotted line represents the example cited in text. SSI = surgical site infection; MRSA = methicillin-resistant Staphylococcus aureus; CNS = coagulase-negative staphylococci; GNB: gram-negative bacteria.

Main Article

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