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Volume 8, Number 2—February 2002


Community-Acquired Klebsiella pneumoniae Bacteremia: Global Differences in Clinical Patterns

Wen-Chien Ko*, David L. Paterson†‡, Anthanasia J. Sagnimeni‡, Dennis S. Hansen§, Anne von Gottberg¶, Sunita Mohapatra#, Jose Maria Casellas**, Herman Goossens††, Lutfiye Mulazimoglu‡‡, Gordon Trenholme#, Keith P. Klugman¶, Joseph G. McCormack‡, and Victor L. Yu†Comments to Author 
Author affiliations: *National Cheng Kung University Medical College, Taiwan; †Veterans Administration Medical Center and University of Pittsburgh, Pittsburgh, Pennsylvania, USA; ‡University of Queensland, Mater Adults Hospital, Brisbane, Australia; §Statens Serum Institut, Copenhagen, Denmark; ¶South African Institute of Medical Research, Johannesburg, South Africa; #Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois, USA; **Sanatorio San Lucas, Buenos Aires, Argentina; ††University Hospital, Antwerp, Belgium; ‡‡Marmara University, Istanbul, Turkey;

Main Article

Table 3

Comparison of the characteristics of patients with community-acquired bacteremic pneumonia due to Klebsiella pneumoniae and other patients with community-acquired K. pneumoniae bacteremia: association between pneumonia and alcoholism and residence in South Africa

Characteristic Bacteremic pneumonia
(n=57) Bacteremia without
pneumonia (n=145) p valuea
Resides in South Africa 25 (44%) 15 (10%) <0.001
Age (years) 53.6 58.6 0.07
Serum creatinineb (mg/dL) 2.1 2.3 0.2
Blood urea nitrogenb (mg/dL) 34.8 37.9 NS
Liver function testsb,c
Serum albumin (g/mL) 2.8 3.1 0.05
Serum bilirubin (mg/dL) 2.8 2.9 NS
AST (IU/mL) 174 303 NS
ALT (IU/mL) 115 189 NS
Underlying disease
Diabetes mellitus (%) 12 (21%) 53 (37%) 0.03
Alcoholism (%) 10 (18%) 6 (4%) 0.007
Malignancy (%) 7 (12%) 36 (25%) 0.05
HIV infection (%) 6 (10%) 1 (1%) 0.002
No underlying disease 23 (40%) 44 (30%) NS (0.17)
Critically ill 21 (37%) 23 (16%) 0.001
Death rate at 14 days (%) 31 (54%) 32 (22%) 0.0001

aNS = not significant at p >0.20; AST = aspartate aminotransferase; ALT = alanine aminotransferase.

bLaboratory values are those taken on first visit to a health-care provider; for continuous variables, the figures in the table are mean values.

cBacteremic patients with liver cirrhosis, acute cholangitis, and liver abscess were excluded from the analysis of liver function tests.

Main Article

1United States: Pittsburgh Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, and Rush-Presbyterian-St. Luke’s Medical Center, Chicago, Illinois; Taiwan: National Cheng Kung University Medical College, Tainan; Australia: Royal Brisbane Hospital, Mater Adults Hospital, and Greenslopes Private Hospital, all in Brisbane; South Africa: Hillbrow Hospital and Baragwanath Hospital, both in Johannesburg; Turkey: Marmara University Hospital, Istanbul; Belgium: University Hospital, Antwerp; and Argentina: San Lucas Hospital and Comunidad Olivos Hospital, both in Buenos Aires.