Volume 8, Number 2—February 2002
Research
Lack of Evidence for Human-to-Human Transmission of Avian Influenza A (H9N2) Viruses in Hong Kong, China 19991
Timothy M. Uyeki*
, Yu-Hoi Chong†, Jacqueline M. Katz*, Wilina Lim†, Yuk-Yin Ho†, Sophia S. Wang*, Thomas H.F. Tsang*, Winnie Wan-Yee Au†, Shuk-Chi Chan†, Thomas Rowe*, Jean Hu-Primmer*, Jensa C. Bell*, William W. Thompson*, Carolyn Buxton Bridges*, Nancy J. Cox*, Kwok-Hang Mak†, and Keiji Fukuda*
, Yu-Hoi Chong†, Jacqueline M. Katz*, Wilina Lim†, Yuk-Yin Ho†, Sophia S. Wang*, Thomas H.F. Tsang*, Winnie Wan-Yee Au†, Shuk-Chi Chan†, Thomas Rowe*, Jean Hu-Primmer*, Jensa C. Bell*, William W. Thompson*, Carolyn Buxton Bridges*, Nancy J. Cox*, Kwok-Hang Mak†, and Keiji Fukuda*
Table 1
Clinical characteristics of two children infected with influenza A (H9N2) viruses, Hong Kong, 1999a
| Patient characteristics | History, symptoms, signs on admission | Treatment received | Laboratory studies | Clinical course | Outcome |
|---|---|---|---|---|---|
| 13-month-old girl; possible failure to thrive; no recent travel | Fever 39.5°C (1 day), poor appetite, vomiting, inflamed oropharynx | Cefuroxime Paracetomol Chloropheniramine Pseudoephedrine - Triprolidine (No antiviral medications) | CRPb 0.12 (mg/dL) (normal ≤0.8 mg/dL); WBC 2.22 x 109; AST 66 IU/L; CXR normal; U/A normal; NP aspirate for influenza A EIA: pos NP aspirate for viral culture: pos for influenza A (H9N2), adenovirus type 3 | Uneventful No fever at discharge Duration of hospitalization March 5-7, 1999 | Recovered, no sequelae |
| 4-year-old girl, mild eczema, asthma, no recent travel | Fever 38.9°C (1 day), malaise, sore throat, headache, vomiting, abdominal pain, diarrhea inflamed oropharynx | Cefuroxime Cefotaxime Beclomethosone Paracetomol (No antiviral medications) | CRP 0.25 (mg/dL); (normal ≤0.8 mg/dL); WBC 12.5 x 109 (82%N, 10%L, 7%M); CXR: normal; blood culture neg; stool culture neg; U/A normal; NP aspirate for influenza A EIA pos; NP aspirate for viral culture pos for influenza A (H9N2) | Persistent fever, no fever at discharge. Duration of hospitalization March 1-8, 1999 | Recovered, no sequelae |
aSource: Epidemiologic investigation by the Hong Kong Department of Health and review of medical records.
bCRP = C-reactive protein; WBC = leukocytes; AST = aspartate aminotransferase; CXR = chest X-ray; U/A = urinalysis; NP = nasopharyngeal; EIA = enzyme immunoassay
1Presented in part at the International Conference on Emerging Infectious Diseases 2000, Atlanta, Georgia, July 2000 (Poster #55), Session 7, July 16-19, 2000.
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